Anuria as a Chief Presentation of Takayasu Arteritis  

作　　者：Sara K. Alrasheed Basel Alheijani Rahmah Alzahrani Shaker Alshehri Sara K. Alrasheed;Basel Alheijani;Rahmah Alzahrani;Shaker Alshehri(Department of Medicine, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, KSA;Department of Radiology, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, KSA)

机构地区：[1]Department of Medicine, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, KSA [2]Department of Radiology, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, KSA

出　　处：《Case Reports in Clinical Medicine》2021年第2期24-33,共10页临床医学病理报告（英文）

摘　　要：Takayasu vasculitis is a rare type of large vessel vasculitis that primarily affects the aorta and its main branches;signs and symptoms are usually due to systemic inflammation or ischemia of an organ or a limb, depending on the group of blood vessels involved. In addition, Takayasu arteritis is associated with increased platelet and coagulation activity, leading to a hypercoagulable state and thrombus formation. We report a case of a 47-year-old male who presented with a history of complete anuria for 3 days and was found to have progressively worsening kidney function. Renal Doppler ultrasound confirmed the presence of bilateral renal artery thrombosis, while contrast-enhanced computed tomography (CECT) of the abdomen and pelvis showed extensive abdominal aortic thrombosis with radiological findings consistent with large vessel vacuities. After catheter-directed thrombolytic therapy of the renal arteries, the patient started producing urine and his kidney function significantly improved. Later, positron emission tomography scan (PET) confirmed large vessel Takayasu arteritis. Echocardiography showed no intracardiac thrombus, along with an extensive work-up for thrombophilia, as autoimmune and vasculitis serology came back negative. This is an extremely rare presentation of Takayasu arteritis, with an unusual recovery of acute renal failure after prolonged anuria due to bilateral renal artery thrombosis.Takayasu vasculitis is a rare type of large vessel vasculitis that primarily affects the aorta and its main branches;signs and symptoms are usually due to systemic inflammation or ischemia of an organ or a limb, depending on the group of blood vessels involved. In addition, Takayasu arteritis is associated with increased platelet and coagulation activity, leading to a hypercoagulable state and thrombus formation. We report a case of a 47-year-old male who presented with a history of complete anuria for 3 days and was found to have progressively worsening kidney function. Renal Doppler ultrasound confirmed the presence of bilateral renal artery thrombosis, while contrast-enhanced computed tomography (CECT) of the abdomen and pelvis showed extensive abdominal aortic thrombosis with radiological findings consistent with large vessel vacuities. After catheter-directed thrombolytic therapy of the renal arteries, the patient started producing urine and his kidney function significantly improved. Later, positron emission tomography scan (PET) confirmed large vessel Takayasu arteritis. Echocardiography showed no intracardiac thrombus, along with an extensive work-up for thrombophilia, as autoimmune and vasculitis serology came back negative. This is an extremely rare presentation of Takayasu arteritis, with an unusual recovery of acute renal failure after prolonged anuria due to bilateral renal artery thrombosis.

关 键 词：TAKAYASU ANURIA VASCULITIS 

分 类 号：R69[医药卫生—泌尿科学]