Recurrent Coronary Artery Thrombosis on Triple Anti-Thrombotic Therapy, Is There a Possible Association with ChAdOx1 nCoV-19 Vaccination?  

作　　者：Phillip Crane Voltaire Nadurata M. Asrar Ul Haq Phillip Crane;Voltaire Nadurata;M. Asrar Ul Haq(Department of Cardiology, The Northern Hospital, Epping, Australia;Department of Cardiology, Bendigo Health, Bendigo, Australia)

机构地区：[1]Department of Cardiology, The Northern Hospital, Epping, Australia [2]Department of Cardiology, Bendigo Health, Bendigo, Australia

出　　处：《Case Reports in Clinical Medicine》2022年第6期234-243,共10页临床医学病理报告（英文）

摘　　要：Background: Vaccines remain the only viable and safe option to control transmission and minimise disease sequelae during the COVID-19 pandemic. Whilst multiple vaccines are available, evidence has emerged regarding the association between the ChAdOx1 nCoV-19 vaccine, platelets and thrombosis, manifesting in thrombotic thrombocytopaenia. Case Summary: We report a case of recurrent coronary artery thrombosis on triple antithrombotic therapy, namely aspirin, clopidogrel, and continuous intravenous heparin, nine days after the ChAdOx1 nCoV-19 vaccine, in a 63-year-old female with no significant history of cardiovascular disease. Conclusion: This case may suggest that the association between platelets, SARS-CoV-2, the ChAdOx1 nCoV-19 vaccine, and coronary thrombosis may remain incompletely understood and warrants further study. Clinicians should remain on high alert if presented with similar circumstances.Background: Vaccines remain the only viable and safe option to control transmission and minimise disease sequelae during the COVID-19 pandemic. Whilst multiple vaccines are available, evidence has emerged regarding the association between the ChAdOx1 nCoV-19 vaccine, platelets and thrombosis, manifesting in thrombotic thrombocytopaenia. Case Summary: We report a case of recurrent coronary artery thrombosis on triple antithrombotic therapy, namely aspirin, clopidogrel, and continuous intravenous heparin, nine days after the ChAdOx1 nCoV-19 vaccine, in a 63-year-old female with no significant history of cardiovascular disease. Conclusion: This case may suggest that the association between platelets, SARS-CoV-2, the ChAdOx1 nCoV-19 vaccine, and coronary thrombosis may remain incompletely understood and warrants further study. Clinicians should remain on high alert if presented with similar circumstances.

关 键 词：ST-Elevation Myocardial Infarction Stent Thrombosis ChAdOx1 nCoV-19 ASTRAZENECA COVID-19 SARS-CoV-2 

分 类 号：R54[医药卫生—心血管疾病]