COVID-19 Induced Mixed Connective Tissue Disease (MCTD)—Case Report  

作　　者：Cintia Nagy-Kardos Dominique Zö ld László Tihanyi Gábor Veress Cintia Nagy-Kardos;Dominique Zöld;László Tihanyi;Gábor Veress(National Heart Institute Balatonfüred, National Institute for Rheumatology and Physiotherapy, Budapest, Hungary)

机构地区：[1]National Heart Institute Balatonfüred, National Institute for Rheumatology and Physiotherapy, Budapest, Hungary

出　　处：《Case Reports in Clinical Medicine》2022年第9期393-398,共6页临床医学病理报告（英文）

摘　　要：Mixed connective tissue disease (MCTD) is a rare systemic autoimmune disorder that damages multiple organs simultaneously and is associated with chronic inflammation, in which the signs of systemic sclerosis, systemic lupus erythematosus, and polymyositis can co-occur. Its distinctive feature and the basis for the diagnosis of MCTD is the presence of an antibody against the uridine-rich RNP of the cell nucleus (Anti-U1-RNP). It has been observed that intercurrent infections can trigger autoimmune diseases, however, the fact that viral infections—such as SARS-CoV-2—induce them is currently poorly understood. The present study raises the etiological role of the SARS-CoV-2 virus in the development of the disease. Authors describe the case of a 38-year-old patient in good general condition, who was diagnosed with mixed connective tissue disease three months after COVID-19 infection.Mixed connective tissue disease (MCTD) is a rare systemic autoimmune disorder that damages multiple organs simultaneously and is associated with chronic inflammation, in which the signs of systemic sclerosis, systemic lupus erythematosus, and polymyositis can co-occur. Its distinctive feature and the basis for the diagnosis of MCTD is the presence of an antibody against the uridine-rich RNP of the cell nucleus (Anti-U1-RNP). It has been observed that intercurrent infections can trigger autoimmune diseases, however, the fact that viral infections—such as SARS-CoV-2—induce them is currently poorly understood. The present study raises the etiological role of the SARS-CoV-2 virus in the development of the disease. Authors describe the case of a 38-year-old patient in good general condition, who was diagnosed with mixed connective tissue disease three months after COVID-19 infection.

关 键 词：Mixed Connective Tissue Disease (MCTD) Anti-U1-RNP Antibody SARS-CoV-2 COVID-19 Infection Post-COVID Syndrome 

分 类 号：R59[医药卫生—内科学]