Analgesic Effect of 35 kDa Hyaluronan Fragment on Vaginal Oocyte Retrieval Operation-Associated Pain: A Case Report  

作　　者：Hua Zhang Dylan Treger Xiaoxiao Jia Zhaohui Ma Mizhou Hui Hua Zhang;Dylan Treger;Xiaoxiao Jia;Zhaohui Ma;Mizhou Hui(Department of Biomedical, Stem Cell Thomas, Chengdu, China;Miller School of Medicine, University of Miami, Florida, USA;Department of Pain Medicine, Hynaut Laboratories, Qingdao, China)

机构地区：[1]Department of Biomedical, Stem Cell Thomas, Chengdu, China [2]Miller School of Medicine, University of Miami, Florida, USA [3]Department of Pain Medicine, Hynaut Laboratories, Qingdao, China

出　　处：《Case Reports in Clinical Medicine》2024年第12期503-511,共9页临床医学病理报告(英文)

摘　　要：Transvaginal oocyte retrieval (TVOR) is a common yet painful procedure in assisted reproductive technologies (ART) like in vitro fertilization (IVF). Effective pain management during and after TVOR is essential, particularly since anesthesia may influence oocyte quality and treatment outcomes. This case report aims to evaluate the analgesic efficacy of 35 kDa hyaluronan fragments (HA35) to manage TVOR-associated pain. A 40-year-old patient with infertility underwent two TVOR procedures ten months apart under nearly identical preparatory conditions, including a subcutaneous injection of recombinant human chorionic gonadotropin to stimulate oocyte maturation. During the first procedure, pain management consisted of diclofenac sodium suppositories alone, while the second procedure included additional subcutaneous and topical HA35 administration alongside diclofenac sodium. The primary outcome measured was the patient’s self-reported pain level on the Numeric Pain Rating Scale (NPRS), alongside secondary indicators of postoperative recovery and discomfort. Results demonstrated that the addition of HA35 reduced the patient’s pain score by half, shortened the duration of pain, significantly improved comfort, and prevented postoperative bleeding, allowing for immediate discharge. This case suggests that HA35 may offer an effective, low-risk approach to enhance analgesia, reduce side effects, and improve patient recovery in TVOR procedures.Transvaginal oocyte retrieval (TVOR) is a common yet painful procedure in assisted reproductive technologies (ART) like in vitro fertilization (IVF). Effective pain management during and after TVOR is essential, particularly since anesthesia may influence oocyte quality and treatment outcomes. This case report aims to evaluate the analgesic efficacy of 35 kDa hyaluronan fragments (HA35) to manage TVOR-associated pain. A 40-year-old patient with infertility underwent two TVOR procedures ten months apart under nearly identical preparatory conditions, including a subcutaneous injection of recombinant human chorionic gonadotropin to stimulate oocyte maturation. During the first procedure, pain management consisted of diclofenac sodium suppositories alone, while the second procedure included additional subcutaneous and topical HA35 administration alongside diclofenac sodium. The primary outcome measured was the patient’s self-reported pain level on the Numeric Pain Rating Scale (NPRS), alongside secondary indicators of postoperative recovery and discomfort. Results demonstrated that the addition of HA35 reduced the patient’s pain score by half, shortened the duration of pain, significantly improved comfort, and prevented postoperative bleeding, allowing for immediate discharge. This case suggests that HA35 may offer an effective, low-risk approach to enhance analgesia, reduce side effects, and improve patient recovery in TVOR procedures.

关 键 词：Transvaginal Oocyte Retrieval 35 kDa Hyaluronan Fragments HA35 ANALGESIA Pain Relief Wound Healing 

分 类 号：R24[医药卫生—中医临床基础]