The Effects of Mild-Hyperbaric Oxygen Therapy on Cognitive Function and Symptom Relief in a 35-Year-Old Male with Post-Concussive Symptoms Following a Motor Vehicle Accident: A Case Report  

作　　者：Daniel Bricker William Sealy Hambright Julian Alberto Syed Asad Daniel Bricker;William Sealy Hambright;Julian Alberto;Syed Asad(Universal Neurological Care, Jacksonville, Florida, USA;Base State Longevity, Aspen, Colorado, USA)

机构地区：[1]Universal Neurological Care, Jacksonville, Florida, USA [2]Base State Longevity, Aspen, Colorado, USA

出　　处：《Case Reports in Clinical Medicine》2025年第1期15-24,共10页临床医学病理报告(英文)

摘　　要：This case report examines the impact of mild hyperbaric oxygen therapy (mHBOT) on cognitive function and symptom relief in a 35-year-old male presenting with concussive symptoms (CS) following a motor vehicle accident (MVA). The patient underwent 10 mHBOT sessions over five weeks (40 minutes per session at 1.5 ATA with 32% oxygen). Post-treatment assessments revealed significant improvements, including an increase in P300 voltage from 4.2 µV to 9.2 µV, aligning with the normative range of 8 - 21 µV. Electroencephalogram (EEG) analysis demonstrated enhanced alpha and theta band activity, reflecting improved cognitive processing and attentional regulation. Clinically, the patient reported reduced headache severity, improved sleep quality, and decreased pain intensity. These findings suggest that mHBOT may support neuroplasticity, mitigate inflammation, and restore cognitive function in patients with CS. Further research, including randomized controlled trials (RCTs), is warranted to validate mHBOT’s efficacy and explore its long-term benefits in traumatic brain injury (TBI) rehabilitation.This case report examines the impact of mild hyperbaric oxygen therapy (mHBOT) on cognitive function and symptom relief in a 35-year-old male presenting with concussive symptoms (CS) following a motor vehicle accident (MVA). The patient underwent 10 mHBOT sessions over five weeks (40 minutes per session at 1.5 ATA with 32% oxygen). Post-treatment assessments revealed significant improvements, including an increase in P300 voltage from 4.2 µV to 9.2 µV, aligning with the normative range of 8 - 21 µV. Electroencephalogram (EEG) analysis demonstrated enhanced alpha and theta band activity, reflecting improved cognitive processing and attentional regulation. Clinically, the patient reported reduced headache severity, improved sleep quality, and decreased pain intensity. These findings suggest that mHBOT may support neuroplasticity, mitigate inflammation, and restore cognitive function in patients with CS. Further research, including randomized controlled trials (RCTs), is warranted to validate mHBOT’s efficacy and explore its long-term benefits in traumatic brain injury (TBI) rehabilitation.

关 键 词：Mild-Hyperbaric Oxygen Post-Concussion Syndrome Holistic Intervention Cognitive Recovery Traumatic Brain Injury 

分 类 号：R65[医药卫生—外科学]