Differential Effects of Ursolic Acid and Oleanolic Acid on Mitochondrial ATP Generation in H9c2 Cardiomyocytes and Lipopolysaccharide-Induced Cell Proliferation in Mouse Splenocytes: Yang versus Yin  

作　　者：Hoi Yan Leung Kai Chit Cheung Kam Ming Ko Hoi Yan Leung;Kai Chit Cheung;Kam Ming Ko(Division of Life Science, Hong Kong University of Science & Technology, Hong Kong, China)

机构地区：[1]Division of Life Science, Hong Kong University of Science & Technology, Hong Kong, China

出　　处：《Chinese Medicine》2021年第3期37-46,共10页中医（英文）

摘　　要：<span style="font-family:Verdana;">In the present study, two cell-based systems for assessing Yang and Yin activities were for the first time used to investigate the effect of ursolic acid (UA) and oleanolic acid (OA). The results indicated that while UA was only active in the Yang assay, OA produced activity in the Yin assay. The Yang/Yin activity of UA/OA may be attributed to their distinct molecular structures, which confer their differential ability to interact with mitochondrial membrane or cellular membrane lipids, with resultant membrane fluidization and potentiation of biological responses.</span><span style="font-family:Verdana;">In the present study, two cell-based systems for assessing Yang and Yin activities were for the first time used to investigate the effect of ursolic acid (UA) and oleanolic acid (OA). The results indicated that while UA was only active in the Yang assay, OA produced activity in the Yin assay. The Yang/Yin activity of UA/OA may be attributed to their distinct molecular structures, which confer their differential ability to interact with mitochondrial membrane or cellular membrane lipids, with resultant membrane fluidization and potentiation of biological responses.</span>

关 键 词：Yang YIN Ursolic Acid Oleanolic Acid Mitochondrial ATP Generation SPLENOCYTES 

分 类 号：R28[医药卫生—中药学]