Technological Advances in Accelerated Wound Repair and Regeneration  

作　　者：Xanya Sofra Nuris Lampe Xanya Sofra;Nuris Lampe(Research and Technology Development, IELLIOS Ltd., Ipwsich, UK;Clinical Dermatology Department of Horatio Oduber Hospital, Oranjestad, Aruba)

机构地区：[1]Research and Technology Development, IELLIOS Ltd., Ipwsich, UK [2]Clinical Dermatology Department of Horatio Oduber Hospital, Oranjestad, Aruba

出　　处：《Health》2020年第7期717-737,共21页健康（英文）

摘　　要：We reviewed a number of wound repair, keloid and hypertrophic scar research methods that included lasers, microcurrent and ultra-low energy technologies. Laser research reports short-term improvement in wounds, keloid and hypertrophic scars, but without follow up to control for reoccurrence of keloids or diabetic lesions which generally reoccur following laser treatments. The microcurrent and ultra-low energy studies demonstrate significant healing where age is not a factor with no reoccurrence of diabetic wounds and other skin lesions. Our randomized, double-blind longitudinal research on eight wound repair clinical cases with an age range of 28 - 86, followed for one year, evidenced accelerated healing and no reoccurrence. The number of treatments required for substantial healing depended on the chronicity and severity of the lesion, with chronic severe lesions requiring more treatments, rather than age, a conclusion supported by ultra-low microcurrent research. These results on age-independent wound healing directly contradict a large body of literature postulating that healing is much slower with age due to immune insufficiency, age-accumulated oxidative stress, disrupted cell communications and sustained inflammation.We reviewed a number of wound repair, keloid and hypertrophic scar research methods that included lasers, microcurrent and ultra-low energy technologies. Laser research reports short-term improvement in wounds, keloid and hypertrophic scars, but without follow up to control for reoccurrence of keloids or diabetic lesions which generally reoccur following laser treatments. The microcurrent and ultra-low energy studies demonstrate significant healing where age is not a factor with no reoccurrence of diabetic wounds and other skin lesions. Our randomized, double-blind longitudinal research on eight wound repair clinical cases with an age range of 28 - 86, followed for one year, evidenced accelerated healing and no reoccurrence. The number of treatments required for substantial healing depended on the chronicity and severity of the lesion, with chronic severe lesions requiring more treatments, rather than age, a conclusion supported by ultra-low microcurrent research. These results on age-independent wound healing directly contradict a large body of literature postulating that healing is much slower with age due to immune insufficiency, age-accumulated oxidative stress, disrupted cell communications and sustained inflammation.

关 键 词：KELOIDS Acute Wounds Hypertrophic Scars Inflammation Eschar Wounds Herpes Zoster Aging Wound Healing Diabetic Lesions 

分 类 号：R62[医药卫生—整形外科]