Regional Coherence Alterations in Patients with Poststroke Cognitive Impairment after Acupuncture Therapy: A Resting-State fMRI Study  

作　　者：Peng Zhang Ran Wang Yue Shi Xiao-Hua Huang Lin Yang Peng Zhang;Ran Wang;Yue Shi;Xiao-Hua Huang;Lin Yang(Science and Technology Innovation Center, Interventional Medical Center, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China;Department of Radiology, Sichuan Province Orthopedic Hospital, Chengdu, China)

机构地区：[1]Science and Technology Innovation Center, Interventional Medical Center, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China [2]Department of Radiology, Sichuan Province Orthopedic Hospital, Chengdu, China

出　　处：《Health》2024年第12期1176-1186,共11页健康(英文)

摘　　要：Objective: To explore regional homogeneity (ReHo) alterations after acupuncture treatment in poststroke cognitive impairment (PSCI) patients. Methods: Twenty-one PSCI patients who underwent acupuncture therapy in our hospital and 12 matched healthy controls were enrolled in this study. All study subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI);for PSCI patients, rs-fMRI scans were conducted before and after acupuncture therapy. Data preprocessing was performed using the DPARSF5.4 and SPM12 toolkits on the MATLAB 2022b platform. DPARSF5.4 was used to calculate the ReHo index of the preprocessed resting-state data. A two-sample t-test was used to compare the differences in ReHo between the PSCI patients group pretreatment and the control group (with sex and age as covariates), and a paired t-test was used to compare the differences in ReHo between the pretreatment and posttreatment groups of PSCI patients (without covariates). AAL_116_binary_mask.nii was used as the statistical mask, and the statistical results were corrected using family-wise error correction, with P Conclusion: PSCI patients exhibited abnormal ReHo in the resting state, and ReHo was significantly altered after acupuncture treatment. The results of this study suggest that ReHo might be a potential biomarker in the diagnosis and treatment of PSCI.Objective: To explore regional homogeneity (ReHo) alterations after acupuncture treatment in poststroke cognitive impairment (PSCI) patients. Methods: Twenty-one PSCI patients who underwent acupuncture therapy in our hospital and 12 matched healthy controls were enrolled in this study. All study subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI);for PSCI patients, rs-fMRI scans were conducted before and after acupuncture therapy. Data preprocessing was performed using the DPARSF5.4 and SPM12 toolkits on the MATLAB 2022b platform. DPARSF5.4 was used to calculate the ReHo index of the preprocessed resting-state data. A two-sample t-test was used to compare the differences in ReHo between the PSCI patients group pretreatment and the control group (with sex and age as covariates), and a paired t-test was used to compare the differences in ReHo between the pretreatment and posttreatment groups of PSCI patients (without covariates). AAL_116_binary_mask.nii was used as the statistical mask, and the statistical results were corrected using family-wise error correction, with P Conclusion: PSCI patients exhibited abnormal ReHo in the resting state, and ReHo was significantly altered after acupuncture treatment. The results of this study suggest that ReHo might be a potential biomarker in the diagnosis and treatment of PSCI.

关 键 词：ACUPUNCTURE Post-Stroke Cognitive Impairment Functional MagneticResonance Imaging Regional Coherence 

分 类 号：R24[医药卫生—中医临床基础]