Potential of Binahong (<i>Anredera cordifolia</i>[Tenore] Steen) in Reducing TNF-<i>α</i>Expression on Regeneration of Pancreas <i>β</i>Cells on White Rats (<i>Rattus norvegicus</i>) Diabetes Mellitus Models  

作　　者：Yuliet G. Latuhihin Theopilus Watuguly Pieter Kakisina Indranila Kustarini Samsuria Yuliet G. Latuhihin;Theopilus Watuguly;Pieter Kakisina;Indranila Kustarini Samsuria(Department Biology Education, Postgraduate Program, Pattimura University, Ambon, Indonesia;Department Biologi, Faculty of Mathematics and Natural Sciences, Pattimura University, Ambon, Indonesia;Department of Clinical Pathology, Diponegoro University, Semarang, Indonesia)

机构地区：[1]Department Biology Education, Postgraduate Program, Pattimura University, Ambon, Indonesia [2]Department Biologi, Faculty of Mathematics and Natural Sciences, Pattimura University, Ambon, Indonesia [3]Department of Clinical Pathology, Diponegoro University, Semarang, Indonesia

出　　处：《Journal of Biosciences and Medicines》2020年第6期37-49,共13页生物科学与医学（英文）

摘　　要：Diabetes mellitus (DM) is a metabolic disorder characterized by increased blood glucose levels (hyperglycemia) due to impaired insulin secretion and/or increased insulin resistance. Providing binahong leaf steeping (<em>Anredera cordifolia</em> [Tenore] Steen) is one alternative treatment for people with diabetes mellitus using medicinal plants. This research was conducted to find out the right concentration by administering binahong leaf steeping to reduce hyperglycemia in STZ induced rat and to analyze administration of binahong leaf steeping in reducing TNF-<em>α</em> expression in pancreatic <em>β</em> cell regeneration. This study used 25 white rats (Rattus novergicus) which were divided into 5 groups: group 1, negative control (K-), group 2, positive control (K+), groups 3, 4, and 5. With STZ induction, each is given a dose of binahong leaf steeping, 50.4 mg/180ml of water;100.8 mg/180ml of water and 151.2 mg/180ml of water for 14 days. The results showed that the administration of binahong leaf steeping to STZ induced rat could reduce glucose rats in a row by 130.00, respectively;117,23 and 112,45 and steeping binahong leaves (<em>Anredera cordifolia</em> [Ten] S) significantly influence the reduction in TNF-<em>α</em> expression in pancreatic <em>β</em> cell regeneration. Thus, this study can be concluded that the right dose to reduce hyperglycemic and regeneration of pancreatic <em></em><em>β</em> cells produced by STZ induced rats is 151.2 mg/180ml of water and statistically influences in reducing TNF-<em>α</em> expression in pancreatic <em>β</em> cell regeneration.Diabetes mellitus (DM) is a metabolic disorder characterized by increased blood glucose levels (hyperglycemia) due to impaired insulin secretion and/or increased insulin resistance. Providing binahong leaf steeping (<em>Anredera cordifolia</em> [Tenore] Steen) is one alternative treatment for people with diabetes mellitus using medicinal plants. This research was conducted to find out the right concentration by administering binahong leaf steeping to reduce hyperglycemia in STZ induced rat and to analyze administration of binahong leaf steeping in reducing TNF-<em>α</em> expression in pancreatic <em>β</em> cell regeneration. This study used 25 white rats (Rattus novergicus) which were divided into 5 groups: group 1, negative control (K-), group 2, positive control (K+), groups 3, 4, and 5. With STZ induction, each is given a dose of binahong leaf steeping, 50.4 mg/180ml of water;100.8 mg/180ml of water and 151.2 mg/180ml of water for 14 days. The results showed that the administration of binahong leaf steeping to STZ induced rat could reduce glucose rats in a row by 130.00, respectively;117,23 and 112,45 and steeping binahong leaves (<em>Anredera cordifolia</em> [Ten] S) significantly influence the reduction in TNF-<em>α</em> expression in pancreatic <em>β</em> cell regeneration. Thus, this study can be concluded that the right dose to reduce hyperglycemic and regeneration of pancreatic <em></em><em>β</em> cells produced by STZ induced rats is 151.2 mg/180ml of water and statistically influences in reducing TNF-<em>α</em> expression in pancreatic <em>β</em> cell regeneration.

关 键 词：Diabetes Melittus (Anredera cordifolia [Tenore] Steen) Streptozotocin (STZ) Cell β Pancreas TNF-α 

分 类 号：R58[医药卫生—内分泌]