The FDA Mandate to Reassess Benzodiazepines: Alprazolam Induces a Positive Conditioned Place-Preference in Male Rats  

作　　者：Cheyenne Moffett Katherine J. Kost Austen Thompson Michael H. Ossipov Joseph V. Pergolizzi Junior Sumiyo Umeda-Raffa Robert B. Raffa Tally M. Largent-Milnes Todd Vanderah Cheyenne Moffett;Katherine J. Kost;Austen Thompson;Michael H. Ossipov;Joseph V. Pergolizzi Junior;Sumiyo Umeda-Raffa;Robert B. Raffa;Tally M. Largent-Milnes;Todd Vanderah(Department of Pharmacology, and Comprehensive Pain and Addiction Center, University of Arizona, Tucson, AZ, USA;Department of Pharmacology, and Comprehensive Pain and Addiction Center, University of Arizona, Tucson, AZ, USA;Neumentum Inc., Morristown, NJ, USA;Enalare Therapeutics, Naples, FL, USA;Pharmaceutical Sciences (Form. Faculty), Hokkaido University of Science, Hokkaido, Japan;Temple University School of Pharmacy (Prof Em.), Philadelphia, PA, USA;College of Pharmacy (Adjunct), University of Arizona, Tucson, AZ, USA)

机构地区：[1]Department of Pharmacology, and Comprehensive Pain and Addiction Center, University of Arizona, Tucson, AZ, USA [2]Department of Pharmacology, and Comprehensive Pain and Addiction Center, University of Arizona, Tucson, AZ, USA [3]Neumentum Inc., Morristown, NJ, USA [4]Enalare Therapeutics, Naples, FL, USA [5]Pharmaceutical Sciences (Form. Faculty), Hokkaido University of Science, Hokkaido, Japan [6]Temple University School of Pharmacy (Prof Em.), Philadelphia, PA, USA [7]College of Pharmacy (Adjunct), University of Arizona, Tucson, AZ, USA

出　　处：《Journal of Biosciences and Medicines》2021年第3期1-8,共8页生物科学与医学（英文）

摘　　要：On September 23, 2020, in order “To address the serious risks of abuse, addiction, physical dependence, and withdrawal reactions, the U.S. Food and Drug Administration (FDA) is requiring the Boxed Warning be updated for all benzodiazepine medicines”. With this announcement, the FDA proclaimed that much more needs to be known about the initiation, continuation, and discontinuation of these widely-used drugs. Unfortunately, relevant information is lacking, since for many years, there has been a notable sparsity in the funding and conduct of basic and clinical research on these drugs. In order to begin to fill the void, it is valuable to (re)examine animal models. We here describe a model of conditioned place-preference (CPP) for rats and for the first time, to our knowledge, show that the representative benzodiazepine alprazolam induces positive place-preference in male rats.On September 23, 2020, in order “To address the serious risks of abuse, addiction, physical dependence, and withdrawal reactions, the U.S. Food and Drug Administration (FDA) is requiring the Boxed Warning be updated for all benzodiazepine medicines”. With this announcement, the FDA proclaimed that much more needs to be known about the initiation, continuation, and discontinuation of these widely-used drugs. Unfortunately, relevant information is lacking, since for many years, there has been a notable sparsity in the funding and conduct of basic and clinical research on these drugs. In order to begin to fill the void, it is valuable to (re)examine animal models. We here describe a model of conditioned place-preference (CPP) for rats and for the first time, to our knowledge, show that the representative benzodiazepine alprazolam induces positive place-preference in male rats.

关 键 词：BENZODIAZEPINES Conditioned Place-Preference ALPRAZOLAM REINFORCEMENT Affective State 

分 类 号：F20[经济管理—国民经济]