Androgens/Androgen Receptor in the Management of Skin Diseases  

作　　者：Xiaoyu Zhou Yu Jiao Wenqiang Zhang Wenhai Li Xiaoyu Zhou;Yu Jiao;Wenqiang Zhang;Wenhai Li(School of Science, China Pharmaceutical University, Nanjing, China)

机构地区：[1]School of Science, China Pharmaceutical University, Nanjing, China

出　　处：《Journal of Biosciences and Medicines》2022年第12期180-200,共21页生物科学与医学（英文）

摘　　要：Beyond regulation of male sexual function, the increasing evidence shows that androgens and androgen receptor (AR) have a variety of physiological and pathological effects on the skin. Skin cells express all androgen metabolizing enzymes that are required for independent skin androgen synthesis and the development of hyperandrogenic related disorders such as acne, hirsutism and androgenetic alopecia. Targeting various elements of androgen function and metabolism is the major goal of medication design for the treatment of androgen-related diseases. Antiandrogen drugs such as clascoterone, flutamide could improve conditions. Even though the involvement of androgens and AR in skin diseases has been investigated for a long time, their molecular mechanisms in skin disorders remain largely insufficient. In this review, recent studies and advances on the role of androgens/AR in several skin-related diseases and their therapeutics are systematically summarized.Beyond regulation of male sexual function, the increasing evidence shows that androgens and androgen receptor (AR) have a variety of physiological and pathological effects on the skin. Skin cells express all androgen metabolizing enzymes that are required for independent skin androgen synthesis and the development of hyperandrogenic related disorders such as acne, hirsutism and androgenetic alopecia. Targeting various elements of androgen function and metabolism is the major goal of medication design for the treatment of androgen-related diseases. Antiandrogen drugs such as clascoterone, flutamide could improve conditions. Even though the involvement of androgens and AR in skin diseases has been investigated for a long time, their molecular mechanisms in skin disorders remain largely insufficient. In this review, recent studies and advances on the role of androgens/AR in several skin-related diseases and their therapeutics are systematically summarized.

关 键 词：ANDROGENS Androgen Receptor Skin Diseases 

分 类 号：R58[医药卫生—内分泌]