Variations in Inflammatory Cells and IL-6 in Long-Distance Runners Susceptible to Exercise-Induced Bronchospasm and Previously Treated with Salbutamol  

作　　者：Florent Nsompi Alain Marc Boussana Paul Roger Mabounda Kounga Albérick Tito Simplice Innocent Moussouami Eddie Janvier Bouhika Folly Messan Florent Nsompi;Alain Marc Boussana;Paul Roger Mabounda Kounga;Albérick Tito;Simplice Innocent Moussouami;Eddie Janvier Bouhika;Folly Messan(Laboratory of Molecular and Cellular Biology, Physical Activity and Health, Higher Institute of Physical Education and Sport (ISEPS), Marien Ngouabi University, Brazzaville, Republic of Congo;Respiratory, Hormonal and Gerontological Sports Explorations Unit, National Institute of Youth, Physical Education and Sport (INJEPS), University of Abomey-Calavi (UAC), Porto-Novo, Benin;Laboratory Education, Health, Expertise and Motor Performance (LESEPM), Brazzaville, Republic of Congo)

机构地区：[1]Laboratory of Molecular and Cellular Biology, Physical Activity and Health, Higher Institute of Physical Education and Sport (ISEPS), Marien Ngouabi University, Brazzaville, Republic of Congo [2]Respiratory, Hormonal and Gerontological Sports Explorations Unit, National Institute of Youth, Physical Education and Sport (INJEPS), University of Abomey-Calavi (UAC), Porto-Novo, Benin [3]Laboratory Education, Health, Expertise and Motor Performance (LESEPM), Brazzaville, Republic of Congo

出　　处：《Journal of Biosciences and Medicines》2023年第1期32-46,共15页生物科学与医学（英文）

摘　　要：Background: Exercise-Induced Bronchospasm (EIB) is an inflammatory condition characterized by severe airway constriction following the mobilization of inflammatory cells and interleukin-6 (IL-6). When severe, EIB can require the use of pressurized salbutamol to treat athletes. This study investigated the nature of the systemic changes in inflammatory cells and post-exercise IL-6 concentrations after salbutamol treatment in EIB-susceptible distance runners. Materials and Methods: This was an experimental study that enrolled 12 long-distance runners. In Session A, the participants completed a treadmill exercise test, and those who had a maximum expiratory volume per second (FEV1) that was decreased by at least 10% compared to their base value were placed in the EIB-susceptible group (EIB+) (n = 6). Those whose FEV1 did not meet this criterion were placed in the nonresponsive (EIB?) group (n = 6). Before the Session B exercise, athletes in the BIE+ group inhaled two puffs of salbutamol (EIB+ Salb), while their EIB? counterparts received no treatment. Spirometry was performed before and after the exercise using a Spirobank G portable spirometer. Blood samples were taken before, immediately after and 2 hours after the stress test. Results: The mean post-exercise FEV1 values were not significantly different (p > 0.05) between the EIB+ Salb group and the EIB? group. The systemic changes in inflammatory cells and IL-6 concentrations in the EIB+ runners after salbutamol treatment were similar to those observed in their EIB? counterparts. Conclusion: Salbutamol pretreatment improved the systemic immune status of EIB-susceptible athletes.Background: Exercise-Induced Bronchospasm (EIB) is an inflammatory condition characterized by severe airway constriction following the mobilization of inflammatory cells and interleukin-6 (IL-6). When severe, EIB can require the use of pressurized salbutamol to treat athletes. This study investigated the nature of the systemic changes in inflammatory cells and post-exercise IL-6 concentrations after salbutamol treatment in EIB-susceptible distance runners. Materials and Methods: This was an experimental study that enrolled 12 long-distance runners. In Session A, the participants completed a treadmill exercise test, and those who had a maximum expiratory volume per second (FEV1) that was decreased by at least 10% compared to their base value were placed in the EIB-susceptible group (EIB+) (n = 6). Those whose FEV1 did not meet this criterion were placed in the nonresponsive (EIB?) group (n = 6). Before the Session B exercise, athletes in the BIE+ group inhaled two puffs of salbutamol (EIB+ Salb), while their EIB? counterparts received no treatment. Spirometry was performed before and after the exercise using a Spirobank G portable spirometer. Blood samples were taken before, immediately after and 2 hours after the stress test. Results: The mean post-exercise FEV1 values were not significantly different (p > 0.05) between the EIB+ Salb group and the EIB? group. The systemic changes in inflammatory cells and IL-6 concentrations in the EIB+ runners after salbutamol treatment were similar to those observed in their EIB? counterparts. Conclusion: Salbutamol pretreatment improved the systemic immune status of EIB-susceptible athletes.

关 键 词：Exercise-Induced Bronchospasm SALBUTAMOL Inflammatory Cells INTERLEUKIN-6 

分 类 号：TU8[建筑科学]