Seroepidemiological Study of Dengue Virus Infection Suspected Cases in Burkina Faso  

作　　者：Kima Donatien Yeri Esther Hien Sawadogo Salam Nebié K. Yacouba Ilboudo P. Denise Abdoul Rahamani Nikièma Diallo Mariam Kafando Eléonore Yves Traoré Kima Donatien;Yeri Esther Hien;Sawadogo Salam;Nebié K. Yacouba;Ilboudo P. Denise;Abdoul Rahamani Nikièma;Diallo Mariam;Kafando Eléonore;Yves Traoré(Université Joseph Ki-Zerbo, Ouagadougou, Burkina Faso;Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle, Ouagadougou, Burkina Faso;Laboratoire de Biochimie et d’Immunologie Appliquée (LaBIA), Université Joseph Ki-Zerbo, Ouagadougou, Burkina Faso;Université de Fada N’Gourma, Fada N’Gourma, Burkina Faso;Institut de Recherche en Science de la Santé (IRSS), Ouagadougou, Burkina Faso)

机构地区：[1]Université Joseph Ki-Zerbo, Ouagadougou, Burkina Faso [2]Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle, Ouagadougou, Burkina Faso [3]Laboratoire de Biochimie et d’Immunologie Appliquée (LaBIA), Université Joseph Ki-Zerbo, Ouagadougou, Burkina Faso [4]Université de Fada N’Gourma, Fada N’Gourma, Burkina Faso [5]Institut de Recherche en Science de la Santé (IRSS), Ouagadougou, Burkina Faso

出　　处：《Journal of Biosciences and Medicines》2023年第1期47-56,共10页生物科学与医学（英文）

摘　　要：Dengue fever is a mosquito-borne disease caused by four related but antigenically distinct dengue viruses. In the last half-century, the prevalence of dengue fever has increased dramatically (up to 30%) worldwide, especially in Sub-Saharan Africa. In Burkina Faso, the last dengue epidemic occurred in 2016, and the epidemiological situation is still poorly documented at the national level. Therefore, the present study aimed to conduct a sentinel seroepidemiology of suspected dengue virus infections from 2017 to 2020 at Charles de Gaulle University Pediatric Hospital Center of Ouagadougou. This investigation was designed to be a descriptive and analytical study. Patients with suspected cases of dengue fever were recruited from January 2017 to December 2020 during general medicine consultation and referred to Charles de Gaulle University Pediatric Hospital Center of Ouagadougou for the serological diagnosis of dengue. Venous blood was collected in dry or EDTA tubes and tested for DENV NS1 antigen, anti-dengue IgM, and anti-dengue IgG using SD Bioline Dengue Duo Rapid Detection Kit (Standard Diagnostic Inc., Korea). A total of 3400 blood samples from clinically suspected dengue cases were analyzed, of which 1784 (52.5%) were males, and 1616 (47.5%) were females. Among the 3400 patients included in the study, 661 (19.4%) were tested at least positive for NS1 antigen, anti-dengue IgM or anti-IgG. Among them, individuals positive for IgG suggesting past dengue virus infection were found in more than a third of 262 (7.7%) of the cases. Approximately, 80.0% (2705/3400) dengue suspected cases and 85.5% (341/399) early or primary dengue infections were recorded in the last four months of the study (September to December 2020), with a peak in mid-October and mid-November. There was no statistically significant difference in seroprevalence between males and females (p = 0.7), but an increasing seropositivity trend with age, from 11.6% for the patient under 5 years group to 39.7% for 30 years and over age group were noted. ThiDengue fever is a mosquito-borne disease caused by four related but antigenically distinct dengue viruses. In the last half-century, the prevalence of dengue fever has increased dramatically (up to 30%) worldwide, especially in Sub-Saharan Africa. In Burkina Faso, the last dengue epidemic occurred in 2016, and the epidemiological situation is still poorly documented at the national level. Therefore, the present study aimed to conduct a sentinel seroepidemiology of suspected dengue virus infections from 2017 to 2020 at Charles de Gaulle University Pediatric Hospital Center of Ouagadougou. This investigation was designed to be a descriptive and analytical study. Patients with suspected cases of dengue fever were recruited from January 2017 to December 2020 during general medicine consultation and referred to Charles de Gaulle University Pediatric Hospital Center of Ouagadougou for the serological diagnosis of dengue. Venous blood was collected in dry or EDTA tubes and tested for DENV NS1 antigen, anti-dengue IgM, and anti-dengue IgG using SD Bioline Dengue Duo Rapid Detection Kit (Standard Diagnostic Inc., Korea). A total of 3400 blood samples from clinically suspected dengue cases were analyzed, of which 1784 (52.5%) were males, and 1616 (47.5%) were females. Among the 3400 patients included in the study, 661 (19.4%) were tested at least positive for NS1 antigen, anti-dengue IgM or anti-IgG. Among them, individuals positive for IgG suggesting past dengue virus infection were found in more than a third of 262 (7.7%) of the cases. Approximately, 80.0% (2705/3400) dengue suspected cases and 85.5% (341/399) early or primary dengue infections were recorded in the last four months of the study (September to December 2020), with a peak in mid-October and mid-November. There was no statistically significant difference in seroprevalence between males and females (p = 0.7), but an increasing seropositivity trend with age, from 11.6% for the patient under 5 years group to 39.7% for 30 years and over age group were noted. Thi

关 键 词：DENGUE SEROEPIDEMIOLOGY OUAGADOUGOU Burkina Faso 

分 类 号：R51[医药卫生—内科学]