BI-D1870 Causes the Rats’ Learning and Memory Acquisition Ability Impairment  

作　　者：Chaojie Zhang Ke He Caixia Li Yazhen Shang Chaojie Zhang;Ke He;Caixia Li;Yazhen Shang(Institute of Traditional Chinese Medicine, Chengde Medical College/Hebei Province Key Research Office of Traditional Chinese Medicine against Dementia/Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development/Hebei Key Laboratory of Nerve Injury and Repair, Chengde, China;The Fourth Hospital of Shijiazhuang, Shijiazhuang, China)

机构地区：[1]Institute of Traditional Chinese Medicine, Chengde Medical College/Hebei Province Key Research Office of Traditional Chinese Medicine against Dementia/Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development/Hebei Key Laboratory of Nerve Injury and Repair, Chengde, China [2]The Fourth Hospital of Shijiazhuang, Shijiazhuang, China

出　　处：《Journal of Biosciences and Medicines》2023年第1期82-97,共16页生物科学与医学（英文）

摘　　要：Aim: To observe the rats’ learning and memory acquisition ability disturbance induced by BI-D1870. Methods: Male SD rats were randomly divided into control group, solvent control group and BI-D1870 group. The rats in the control group were intraperitoneally injected with saline, while those in the solvent control group were intraperitoneally injected with DMSO + sulfobutyl-β-cyclodextrin solvent, and those in the BI-D1870 group were intraperitoneally injected with BI-D1870. All the rats’ appearance and behavior were daily observed, and body weight was recorded on the day 15, 30, 45, 60, 75 and 82 of BI-D1870 injected. Morris water maze was used to screen the rats’ learning and memory acquisition ability on the day 22 - 25, 52 - 55, and 82 - 85 of training by BI-D1870 treated. The successful rates of the rats’ memory impairment were respectively calculated for three times screening. Results: During the whole experiment, there was no obvious difference in appearance and fur color in all rats. The rats’ agitation began to appear on the day 10th of BI-D1870 given. The agitation rats’ number and rats’ body weight gradually increased along with BI-D1870 treated (P P Conclusion: Intraperitoneal injection of BI-D1870 can induce the rats’ learning and memory acquisition ability disorder.Aim: To observe the rats’ learning and memory acquisition ability disturbance induced by BI-D1870. Methods: Male SD rats were randomly divided into control group, solvent control group and BI-D1870 group. The rats in the control group were intraperitoneally injected with saline, while those in the solvent control group were intraperitoneally injected with DMSO + sulfobutyl-β-cyclodextrin solvent, and those in the BI-D1870 group were intraperitoneally injected with BI-D1870. All the rats’ appearance and behavior were daily observed, and body weight was recorded on the day 15, 30, 45, 60, 75 and 82 of BI-D1870 injected. Morris water maze was used to screen the rats’ learning and memory acquisition ability on the day 22 - 25, 52 - 55, and 82 - 85 of training by BI-D1870 treated. The successful rates of the rats’ memory impairment were respectively calculated for three times screening. Results: During the whole experiment, there was no obvious difference in appearance and fur color in all rats. The rats’ agitation began to appear on the day 10th of BI-D1870 given. The agitation rats’ number and rats’ body weight gradually increased along with BI-D1870 treated (P P Conclusion: Intraperitoneal injection of BI-D1870 can induce the rats’ learning and memory acquisition ability disorder.

关 键 词：BI-D1870 Learning and Memory Acquisition Impairment Morris Water Maze RSK Inhibitor 

分 类 号：R28[医药卫生—中药学]