What Is the Difference between Post- and Pre-Dilution in On-Line Haemodiafiltration in the Removing of Median-Molecular-Weight Toxins?  

作　　者：Konstantinos S. Mavromatidis Irini M. Kalogiannidou Ploumis S. Passadakis Konstantinos S. Mavromatidis;Irini M. Kalogiannidou;Ploumis S. Passadakis(Renal Unit “Dimokrition”, Komotini, Greece)

机构地区：[1]Renal Unit “Dimokrition”, Komotini, Greece

出　　处：《Journal of Biosciences and Medicines》2023年第3期105-119,共15页生物科学与医学（英文）

摘　　要：Introduction: β₂-microglobulin and prolactin are medium-molecular-weight toxins. We believe that the rate of removal of these molecules, using filters with two different surfaces, in post- and pre-dilution haemodiafiltration, will be of interest to the literature. Methods: We studied, in 12 haemodialyzed patients, the removal of those, with filter with surface of 2.5 m² (Group A) or 2.1 m² (Group B) with post-dilution haemodiafiltration, and with a filter with surface 2.5 m² with pre-dilution (Group C). Results: Satisfactory removal of β₂-microglobulin (best with post-dilution) was found, and a good rate of removal of prolactin without the filter surface played a role in both cases. Conclusion: The elimination of β₂-microglobulin in post-dilution is not affected by the filter surface area. Pre-dilution achieves removal of β₂-microglobulin, less than that of post-dilution. Prolactin was removed satisfactorily regardless of the filter surface in post-dilution, and its removal appears to be less than that of β₂-microglobulin.Introduction: β₂-microglobulin and prolactin are medium-molecular-weight toxins. We believe that the rate of removal of these molecules, using filters with two different surfaces, in post- and pre-dilution haemodiafiltration, will be of interest to the literature. Methods: We studied, in 12 haemodialyzed patients, the removal of those, with filter with surface of 2.5 m² (Group A) or 2.1 m² (Group B) with post-dilution haemodiafiltration, and with a filter with surface 2.5 m² with pre-dilution (Group C). Results: Satisfactory removal of β₂-microglobulin (best with post-dilution) was found, and a good rate of removal of prolactin without the filter surface played a role in both cases. Conclusion: The elimination of β₂-microglobulin in post-dilution is not affected by the filter surface area. Pre-dilution achieves removal of β₂-microglobulin, less than that of post-dilution. Prolactin was removed satisfactorily regardless of the filter surface in post-dilution, and its removal appears to be less than that of β₂-microglobulin.

关 键 词：HAEMODIAFILTRATION Pre-Dilution Post-Dilution β₂-Microglobulin Prolactin 

分 类 号：TN7[电子电信—电路与系统]