Mechanism of Niacin Induced Hot Flushes and Suppression of Cholesterol  

作　　者：Thirugnana Subramanian Thirugnana Subramanian(Department of Pediatric Hematology and Oncology, Washington University School of Medicine, Saint Louis, USA)

机构地区：[1]Department of Pediatric Hematology and Oncology, Washington University School of Medicine, Saint Louis, USA

出　　处：《Journal of Biosciences and Medicines》2023年第5期233-238,共6页生物科学与医学（英文）

摘　　要：Niacin or nicotinic acid is a form of B3 vitamin prescribed at higher concentrations for the suppression of cholesterol levels. Supplemental doses may cause very little or no side effects. However, higher concentrations of niacin cause hot flushes for most people. Here we propose a biochemical mechanism of niacin induced hot flushes. Orally taken prescription doses of niacin are converted to NAD with the liberation of excess pyrophosphate which in turn releases energy in the form of heat (hot flushes through capsaicin receptor) by the action of pyrophosphatases. The excess pyrophosphate may suppress cholesterol biosynthesis through feedback mechanism. The pathways of NAD and cholesterol biosynthesis were discussed with refence to the production and function of pyrophosphate.Niacin or nicotinic acid is a form of B3 vitamin prescribed at higher concentrations for the suppression of cholesterol levels. Supplemental doses may cause very little or no side effects. However, higher concentrations of niacin cause hot flushes for most people. Here we propose a biochemical mechanism of niacin induced hot flushes. Orally taken prescription doses of niacin are converted to NAD with the liberation of excess pyrophosphate which in turn releases energy in the form of heat (hot flushes through capsaicin receptor) by the action of pyrophosphatases. The excess pyrophosphate may suppress cholesterol biosynthesis through feedback mechanism. The pathways of NAD and cholesterol biosynthesis were discussed with refence to the production and function of pyrophosphate.

关 键 词：Cholesterol Biosynthesis NAD NIACIN NIACINAMIDE PYROPHOSPHATE 

分 类 号：X79[环境科学与工程—环境工程]