Hypotensive Effects of an Aqueous Extract of Bambusa vulgaris (Poaceae) Leaves in Rabbit Oryctolagus cuniculus  

作　　者：Appy Simone Abé Kouao Augustin Amonkan Kacou Jules Marius Djétouan Koffi Joseph N’guessan N’dah Etchien Christelle Ekra Kesse Philippe N’da Koffi Bruno Koko Akoua Jeanne Kanga Appy Simone Abé;Kouao Augustin Amonkan;Kacou Jules Marius Djétouan;Koffi Joseph N’guessan;N’dah Etchien Christelle Ekra;Kesse Philippe N’da;Koffi Bruno Koko;Akoua Jeanne Kanga(UPR-Nutrition and Pharmacology, Laboratory of Biology and Health, UFR-Biosciences, Félix Houphouë,t-Boigny University, Abidjan, Cõ,te d’Ivoire;UPR-Animal Physiology, Phytotherapy and Pharmacology, Laboratory of Biology and Health, UFR-Biosciences, Félix Houphouë,t-Boigny University, Abidjan, Cõ,te d’Ivoire;Laboratory of Industrial Processes, Synthesis, Environment and New Energy (LAPISEN), Institute National Polytechnique Félix Houphouë,t-Boigny, Yamoussoukro, Cõ,te d’Ivoire)

机构地区：[1]UPR-Nutrition and Pharmacology, Laboratory of Biology and Health, UFR-Biosciences, Félix Houphouë,t-Boigny University, Abidjan, Cõ,te d’Ivoire [2]UPR-Animal Physiology, Phytotherapy and Pharmacology, Laboratory of Biology and Health, UFR-Biosciences, Félix Houphouë,t-Boigny University, Abidjan, Cõ,te d’Ivoire [3]Laboratory of Industrial Processes, Synthesis, Environment and New Energy (LAPISEN), Institute National Polytechnique Félix Houphouë,t-Boigny, Yamoussoukro, Cõ,te d’Ivoire

出　　处：《Journal of Biosciences and Medicines》2023年第8期51-59,共9页生物科学与医学（英文）

摘　　要：Plant of Bambusa vulgaris is used in traditional medicine practice for the management of many pathologies including hypertension. The effect of the aqueous extract of the leaves of Bambusa vulgaris on blood pressure was evaluated in normotensive male rabbits. Blood pressure was measured by the invasive method. Thus, aqueous extract of Bambusa vulgaris leaves had been injected intravenously at doses ranging from 1 mg/kg to 30 mg/kg in rabbits anesthetized with thiopental. The effects of this extract on blood pressure were also evaluated in rabbits having previously received different doses of atropine. The aqueous extract of Bambusa vulgaris leaves induced a dose-dependent hypotension which is not canceled in the presence of atropine. The results obtained show that the extract has blood pressure lowering effect which may be mediated by muscarinic-type cholinergic receptors.Plant of Bambusa vulgaris is used in traditional medicine practice for the management of many pathologies including hypertension. The effect of the aqueous extract of the leaves of Bambusa vulgaris on blood pressure was evaluated in normotensive male rabbits. Blood pressure was measured by the invasive method. Thus, aqueous extract of Bambusa vulgaris leaves had been injected intravenously at doses ranging from 1 mg/kg to 30 mg/kg in rabbits anesthetized with thiopental. The effects of this extract on blood pressure were also evaluated in rabbits having previously received different doses of atropine. The aqueous extract of Bambusa vulgaris leaves induced a dose-dependent hypotension which is not canceled in the presence of atropine. The results obtained show that the extract has blood pressure lowering effect which may be mediated by muscarinic-type cholinergic receptors.

关 键 词：Bambusa vulgaris Aqueous Extract Hypotensive Effects Oryctolagus cuniculus Rabbits ATROPINE 

分 类 号：R28[医药卫生—中药学]