Health Impacts and Mechanisms of Per- and Polyfluoroalkyl Substances (PFAS) from Epidemiological to Toxicological  

作　　者：Godspower Oghenemaroh Sebe Ebuka Victor Anyaogu Adeyemo David Adebowale Raymond Chidozie Ntomchukwu Supreme O. Oghenerhoro Ogbole E. Jonathan Godspower Oghenemaroh Sebe;Ebuka Victor Anyaogu;Adeyemo David Adebowale Raymond Chidozie Ntomchukwu;Supreme O. Oghenerhoro;Ogbole E. Jonathan(Department of Chemical, Chemistry and Biomedical Engineering, University of New Haven, West Haven, USA;Department of Cell and Molecular Biology, University of New Haven, West Haven, USA;Department of Chemistry and Biochemistry, University of Toledo, Toledo, USA;Department of Chemical Engineering, Chukwuemeka Odumegwu Ojukwu University, Uli, Nigeria)

机构地区：[1]Department of Chemical, Chemistry and Biomedical Engineering, University of New Haven, West Haven, USA [2]Department of Cell and Molecular Biology, University of New Haven, West Haven, USA [3]Department of Chemistry and Biochemistry, University of Toledo, Toledo, USA [4]Department of Chemical Engineering, Chukwuemeka Odumegwu Ojukwu University, Uli, Nigeria

出　　处：《Journal of Biosciences and Medicines》2023年第12期218-240,共20页生物科学与医学（英文）

摘　　要：This research provides a comprehensive analysis of the health impacts of Per- and Polyfluoroalkyl Substances (PFAS) through an integration of epidemiological and toxicological studies. The study identifies significant correlations between PFAS exposure and adverse health outcomes, including thyroid dysfunction, elevated cholesterol levels, and increased risk of specific cancers. Utilizing a mixed-methods approach, the research combines a systematic review and meta-analysis of recent literature with in vitro and in vivo toxicological experiments. The epidemiological analysis reveals increased risks of thyroid dysfunction, cholesterol elevation, and certain cancers among PFAS-exposed individuals. Toxicological findings further corroborate these results, showing dose-dependent cytotoxic effects in human cell lines and endocrine disruption in rodent models. The study emphasizes the importance of regulatory measures to mitigate PFAS exposure and the urgent need for more comprehensive research into their long-term effects. The integration of epidemiological and toxicological data underscores the significant health risks posed by PFAS, highlighting the necessity of immediate action to limit exposure and develop safer alternatives.This research provides a comprehensive analysis of the health impacts of Per- and Polyfluoroalkyl Substances (PFAS) through an integration of epidemiological and toxicological studies. The study identifies significant correlations between PFAS exposure and adverse health outcomes, including thyroid dysfunction, elevated cholesterol levels, and increased risk of specific cancers. Utilizing a mixed-methods approach, the research combines a systematic review and meta-analysis of recent literature with in vitro and in vivo toxicological experiments. The epidemiological analysis reveals increased risks of thyroid dysfunction, cholesterol elevation, and certain cancers among PFAS-exposed individuals. Toxicological findings further corroborate these results, showing dose-dependent cytotoxic effects in human cell lines and endocrine disruption in rodent models. The study emphasizes the importance of regulatory measures to mitigate PFAS exposure and the urgent need for more comprehensive research into their long-term effects. The integration of epidemiological and toxicological data underscores the significant health risks posed by PFAS, highlighting the necessity of immediate action to limit exposure and develop safer alternatives.

关 键 词：PFAS Public Health EPIDEMIOLOGY TOXICOLOGY Endocrine Disruption CARCINOGENICITY Environmental Policy Chemical 

分 类 号：X70[环境科学与工程—环境工程]