Evaluation of Acute and Subacute Toxicities of a Recipe Based on Three Leafy Vegetables in Laboratory Rodents  

作　　者：Lewis Raud Miamb Bonaventure Max Lazare Peneme Berthrand Stéphane Lingomo Wossolo Arnaud Wilfrid Etou Ossibi Lewis Raud Miamb;Bonaventure Max Lazare Peneme;Berthrand Stéphane Lingomo Wossolo;Arnaud Wilfrid Etou Ossibi(Laboratory for the Valorization of Agro-Resources, Ecole Nationale Suprieure Polytechnique, Marien Ngouabi University, Brazzaville, Congo;Laboratory of Pharmacodynamics and Experimental Physiopathology, Faculty of Science and Technology, Marien Ngouabi University, Brazzaville, Congo;Laboratory of Biochemistry and Pharmacology, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congo)

机构地区：[1]Laboratory for the Valorization of Agro-Resources, Ecole Nationale Suprieure Polytechnique, Marien Ngouabi University, Brazzaville, Congo [2]Laboratory of Pharmacodynamics and Experimental Physiopathology, Faculty of Science and Technology, Marien Ngouabi University, Brazzaville, Congo [3]Laboratory of Biochemistry and Pharmacology, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congo

出　　处：《Journal of Biosciences and Medicines》2024年第12期67-78,共12页生物科学与医学(英文)

摘　　要：The consumption of a mixture of leafy vegetables has always been a practice anchored in the dietary habits of the people of Brazzaville. The objective of this study was to evaluate the acute and subacute toxicities of the aqueous extract of the recipe based on three leafy vegetables (Amaranthus hybridus L., Spinacia oleracea, Brassica campestris L.) in laboratory rodents. The aqueous extract of the food recipe was administered orally using a cannula. Regarding acute toxicity, the administration of single doses of 5000 and 10,000 mg/kg to mice had no significant effects on behavior. On the other hand, weight loss was significantly (**p < 0.01) compared to control mice (1 mL/100g). The results on subacute toxicity showed that daily administration of the aqueous extract of the food recipe at a dose of 1000 mg/kg for 21 days in rats resulted in a non-significant weight gain, and caused changes in some biochemical parameters including HDL-cholesterol levels, blood sugar levels and ALAT activity.The consumption of a mixture of leafy vegetables has always been a practice anchored in the dietary habits of the people of Brazzaville. The objective of this study was to evaluate the acute and subacute toxicities of the aqueous extract of the recipe based on three leafy vegetables (Amaranthus hybridus L., Spinacia oleracea, Brassica campestris L.) in laboratory rodents. The aqueous extract of the food recipe was administered orally using a cannula. Regarding acute toxicity, the administration of single doses of 5000 and 10,000 mg/kg to mice had no significant effects on behavior. On the other hand, weight loss was significantly (**p < 0.01) compared to control mice (1 mL/100g). The results on subacute toxicity showed that daily administration of the aqueous extract of the food recipe at a dose of 1000 mg/kg for 21 days in rats resulted in a non-significant weight gain, and caused changes in some biochemical parameters including HDL-cholesterol levels, blood sugar levels and ALAT activity.

关 键 词：Leafy Vegetable Food Recipe Acute Toxicity Subacute Toxicity Biochemical Parameters 

分 类 号：R28[医药卫生—中药学]