Expanded Follicle-Sulcus-Crack Complex Is an Early Warning Sign of Facial Skin Aging: Improvement by Application of Galactomyces Ferment Filtrate-Containing Skin Product  

作　　者：Kukizo Miyamoto Bandara Dissanayake Shenal Wanigasekara Keisuke Fujii Xianghong Yan Masutaka Furue Kukizo Miyamoto;Bandara Dissanayake;Shenal Wanigasekara;Keisuke Fujii;Xianghong Yan;Masutaka Furue(Research and Development, Kobe Innovation Center, Procter and Gamble Innovation GK, Kobe, Japan;Department of Research and Development, Beauty Technology Division, P&G Company, Cincinnati, USA;Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan)

机构地区：[1]Research and Development, Kobe Innovation Center, Procter and Gamble Innovation GK, Kobe, Japan [2]Department of Research and Development, Beauty Technology Division, P&G Company, Cincinnati, USA [3]Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

出　　处：《Journal of Cosmetics, Dermatological Sciences and Applications》2023年第2期91-106,共16页化妆品、皮肤病及应用期刊（英文）

摘　　要：Background: Wrinkles, pigmented spots, and roughness are representative parameters reflecting facial skin aging. Sulci cutis connecting to follicular orifices frequently form perifollicular cracks, which join together adjacent sulci. This follicle-sulcus-crack complex (FSCC) is exacerbated by dehydration. Purpose: Although dehydration is associated with facial skin aging, FSCC’s implications in facial skin aging remain unresolved. Method: We measured facial skin parameters in 1999 and 2010 in 108 Japanese women, and in 2006 and 2016 in 182 Chinese women. We addressed whether expansion of FSCC is associated with other skin aging parameters. We also examined whether skin moisturizer can reverse the expanded FSCC. Results: In both clinical studies, FSCC severity as well as wrinkles, spots, and roughness significantly deteriorated with age. Notably, FSCC significantly increased as early as in subjects in their 20s, whereas wrinkles, spots, and roughness became conspicuous in those in their 40s or older. Moreover, subjects with more severe FSCC in the initial measurement exhibited significantly worse wrinkles, spots, and roughness in the second measurement a decade later. Dehydration was significantly correlated with expanded FSCC. Furthermore, FSCC expansion was reversed after appropriate moisturization by daily application of Galactomyces ferment filtrate (GFF)-containing skincare product (SK-II Skin Power Cream) for 4 weeks in 37 women. Conclusion: The expanded FSCC is likely to be an early indicator of facial skin aging. Appropriate moisturization may reduce FSCC formation and decelerate facial skin aging.Background: Wrinkles, pigmented spots, and roughness are representative parameters reflecting facial skin aging. Sulci cutis connecting to follicular orifices frequently form perifollicular cracks, which join together adjacent sulci. This follicle-sulcus-crack complex (FSCC) is exacerbated by dehydration. Purpose: Although dehydration is associated with facial skin aging, FSCC’s implications in facial skin aging remain unresolved. Method: We measured facial skin parameters in 1999 and 2010 in 108 Japanese women, and in 2006 and 2016 in 182 Chinese women. We addressed whether expansion of FSCC is associated with other skin aging parameters. We also examined whether skin moisturizer can reverse the expanded FSCC. Results: In both clinical studies, FSCC severity as well as wrinkles, spots, and roughness significantly deteriorated with age. Notably, FSCC significantly increased as early as in subjects in their 20s, whereas wrinkles, spots, and roughness became conspicuous in those in their 40s or older. Moreover, subjects with more severe FSCC in the initial measurement exhibited significantly worse wrinkles, spots, and roughness in the second measurement a decade later. Dehydration was significantly correlated with expanded FSCC. Furthermore, FSCC expansion was reversed after appropriate moisturization by daily application of Galactomyces ferment filtrate (GFF)-containing skincare product (SK-II Skin Power Cream) for 4 weeks in 37 women. Conclusion: The expanded FSCC is likely to be an early indicator of facial skin aging. Appropriate moisturization may reduce FSCC formation and decelerate facial skin aging.

关 键 词：Facial Skin Aging Follicle-Sulcus-Crack Complex DEHYDRATION Hyperpigmented Spot WRINKLE Galactomyces Ferment Filtrate 

分 类 号：TG1[金属学及工艺—金属学]