Effect of Diabetes Mellitus on Male Reproductive Hormone of Diabetic Patients Attending Urology Unit of Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria  

作　　者：Simon Uzor Mercy Chinedum Ajuka Isaac Uzor Ugonna Cassandra Aniokete Favour Ebere Nwadum Blessing Njideka Igwe Onyebuchi Frederick Orinya Ogwuegbu Alozie Okezie Emmanuel Obasi Ihuoma A. Obi Oluchi Miracle Ehugbo Joseph Daberechi Oshibe Innocent Icha Imakwu Gift Chinyere Onwe Simon Uzor;Mercy Chinedum Ajuka;Isaac Uzor;Ugonna Cassandra Aniokete;Favour Ebere Nwadum;Blessing Njideka Igwe;Onyebuchi Frederick Orinya;Ogwuegbu Alozie Okezie;Emmanuel Obasi;Ihuoma A. Obi;Oluchi Miracle Ehugbo;Joseph Daberechi Oshibe;Innocent Icha Imakwu;Gift Chinyere Onwe(Department of Medical Laboratory Science, David Umahi Federal University of Health Sciences, Uburu, Nigeria;International Institute for Oncology and Cancer Research, David Umahi Federal University of Health Sciences, Uburu, Nigeria;Department of Medical Laboratory Science, Ebonyi State University, Ebonyi, Nigeria;Department of Medical Laboratory Science, National Obstetrics and Fistula Center, Abakaliki, Nigeria;International Institute for Infectious Diseases, Biosafety and Biosecurity Research of David Umahi Federal University of Health Sciences, Uburu, Nigeria;Department of Medical Biochemistry, David Umahi Federal University of Health Sciences, Uburu, Nigeria;Department of Medical Laboratory Science, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria;International Institute for Cardiovascular Diseases, David Umahi Federal University of Health Sciences, Uburu, Nigeria;Department of Nursing Science, Ebonyi State University, Abakaliki, Nigeria;Department of Pharmacology and Therapeutics, David Umahi Federal University of Health Sciences, Uburu, Nigeria)

机构地区：[1]Department of Medical Laboratory Science, David Umahi Federal University of Health Sciences, Uburu, Nigeria [2]International Institute for Oncology and Cancer Research, David Umahi Federal University of Health Sciences, Uburu, Nigeria [3]Department of Medical Laboratory Science, Ebonyi State University, Ebonyi, Nigeria [4]Department of Medical Laboratory Science, National Obstetrics and Fistula Center, Abakaliki, Nigeria [5]International Institute for Infectious Diseases, Biosafety and Biosecurity Research of David Umahi Federal University of Health Sciences, Uburu, Nigeria [6]Department of Medical Biochemistry, David Umahi Federal University of Health Sciences, Uburu, Nigeria [7]Department of Medical Laboratory Science, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria [8]International Institute for Cardiovascular Diseases, David Umahi Federal University of Health Sciences, Uburu, Nigeria [9]Department of Nursing Science, Ebonyi State University, Abakaliki, Nigeria [10]Department of Pharmacology and Therapeutics, David Umahi Federal University of Health Sciences, Uburu, Nigeria

出　　处：《Journal of Diabetes Mellitus》2025年第1期59-70,共12页糖尿病(英文)

摘　　要：Background: Diabetes is a set of metabolic abnormalities typified by hyperglycemia believed to be associated with aberrant insulin secretion, insulin action, or both. Erectile dysfunction and infertility are globally prevalent complications among male diabetic patients. There is a need to understand the role of a male reproductive hormone in the etiology of infertility in diabetic patients. Objective: This study aims to determine the effect of diabetes mellitus on the Male reproductive hormone (testosterone) on diabetic patients attending the Urology unit of Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria and the effect of industrial sugar consumption in rats model. Materials and Methods: 30 samples (including repeats, n = 3) were collected from known diabetic patients and 30 (including repeats, n = 3) control-non diabetic healthy individuals. Five millilitres (5 ml) of blood was collected from the antecubital vein of each participant and placed into a plain container for serum testosterone measurement using the enzyme-linked immunoassay technique. Blood was also collected from the same subjects in a fluoride oxalate container for plasma enzymatic glucose estimation using a Randox Glucose oxidase kit. For in vivo rat model, the albino rats were grouped into 2 of five (5) rats. The control group (1) was only given normal rat food and water while the test group (2) was treated with 0.4 g of industrial sugar/mL/body weight in addition to rat food and water via oral intubation for 21 days. Blood samples were collected via ocular puncture into plain tubes for testosterone measurement as described above. Results: There is a significant (p Conclusion: In conclusion, data available from this study suggests that increased plasma glucose levels and excessive industrial sugar consumption are associated with decreased testosterone levels in both human and animal models respectively. The mechanism is yet unclear but it could be that DM alters conventional sperm parameters, spermatogenesis, and biosyntheBackground: Diabetes is a set of metabolic abnormalities typified by hyperglycemia believed to be associated with aberrant insulin secretion, insulin action, or both. Erectile dysfunction and infertility are globally prevalent complications among male diabetic patients. There is a need to understand the role of a male reproductive hormone in the etiology of infertility in diabetic patients. Objective: This study aims to determine the effect of diabetes mellitus on the Male reproductive hormone (testosterone) on diabetic patients attending the Urology unit of Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria and the effect of industrial sugar consumption in rats model. Materials and Methods: 30 samples (including repeats, n = 3) were collected from known diabetic patients and 30 (including repeats, n = 3) control-non diabetic healthy individuals. Five millilitres (5 ml) of blood was collected from the antecubital vein of each participant and placed into a plain container for serum testosterone measurement using the enzyme-linked immunoassay technique. Blood was also collected from the same subjects in a fluoride oxalate container for plasma enzymatic glucose estimation using a Randox Glucose oxidase kit. For in vivo rat model, the albino rats were grouped into 2 of five (5) rats. The control group (1) was only given normal rat food and water while the test group (2) was treated with 0.4 g of industrial sugar/mL/body weight in addition to rat food and water via oral intubation for 21 days. Blood samples were collected via ocular puncture into plain tubes for testosterone measurement as described above. Results: There is a significant (p Conclusion: In conclusion, data available from this study suggests that increased plasma glucose levels and excessive industrial sugar consumption are associated with decreased testosterone levels in both human and animal models respectively. The mechanism is yet unclear but it could be that DM alters conventional sperm parameters, spermatogenesis, and biosynthe

关 键 词：Diabetes MELLITUS Reproductive Hormone TESTOSTERONE Industrial Sugar 

分 类 号：R58[医药卫生—内分泌]