Evaluation of Tuberculosis Treatment Outcome of TB/HIV Co-Infection: A Four-Year Retrospective Cohort Study in HIV-Prevalent Setting of North Central Nigeria  

作　　者：Abiodun Hassan Richard Olukolade Queen Ogbuji Audu Onyemocho Lucia Okwuonye Shember-agela Igbabul Josephine Okechukwu Oluremilekun Kusimo Adewale Osho Kehinde Osinowo Oladapo Ladipo Abiodun Hassan;Richard Olukolade;Queen Ogbuji;Audu Onyemocho;Lucia Okwuonye;Shember-agela Igbabul;Josephine Okechukwu;Oluremilekun Kusimo;Adewale Osho;Kehinde Osinowo;Oladapo Ladipo(Association for Reproductive and Family Health, Abuja, Nigeria;Department of Community Health, Benue state University, Makurdi, Nigeria;Benue state Tuberculosis and Leprosy Control Programme, Ministry of Health, Makurdi, Nigeria;FCT Tuberculosis and Leprosy Control Programme, FCT Health Management Board, FCT, Abuja, Nigeria)

机构地区：[1]Association for Reproductive and Family Health, Abuja, Nigeria [2]Department of Community Health, Benue state University, Makurdi, Nigeria [3]Benue state Tuberculosis and Leprosy Control Programme, Ministry of Health, Makurdi, Nigeria [4]FCT Tuberculosis and Leprosy Control Programme, FCT Health Management Board, FCT, Abuja, Nigeria

出　　处：《Journal of Tuberculosis Research》2016年第3期122-133,共12页结核病研究（英文）

摘　　要：Background: Despite the availability of highly effective treatment for decades, Tuberculosis (TB) remains a major health problem in Nigeria due to the increasing association between HIV and TB observed over the past three decades when HIV was discovered. However, the proportion of TB and or TB/HIV co-infected patients who have successful TB treatment outcome is not well known. This study determined the treatment outcome of TB/HIV co-infected patients with HIV negative patients in two states in Nigeria. Materials and Methods: A retrospective study of secondary data from eight Directly Observed Treatment Short (DOTS) course and Anti- Retroviral Therapy (ART) service providers in Benue and Federal Capital Territory (FCT), Nigeria, was carried out. The period under review covers January, 2010 to December, 2013. Results: Out of the total 5266 TB cases reviewed, the HIV prevalence rate was 52%. They were predominantly (53.3%) male with mean age of 34.4 years (SD = 15.1 years). More than two-third (72.5%) of HIV-negative patients had successful treatment compared to 1718 (62.7%) HIV-positive patients. Of the 2334 HIV co-infected patients, 19.5% defaulted, 11.5% had died, 5.6% were transferred out and 0.7% failed treatment compared to HIV-negative patients amongst whom 18.3% defaulted, 3.6% died, 3.9% were transferred out and 1.6% failed treatment (p Conclusion: The favourable treatment outcome of HIV-negative patients is more than that of HIV-positive patients and the most probable predictable factor responsible is the CD4 count of patient;indicating that TB/HIV co-infection has remained a major public health problem in Benue state and FCT. Hence there is the need for sustained strengthening and expansion of the national TB/HIV programmes.Background: Despite the availability of highly effective treatment for decades, Tuberculosis (TB) remains a major health problem in Nigeria due to the increasing association between HIV and TB observed over the past three decades when HIV was discovered. However, the proportion of TB and or TB/HIV co-infected patients who have successful TB treatment outcome is not well known. This study determined the treatment outcome of TB/HIV co-infected patients with HIV negative patients in two states in Nigeria. Materials and Methods: A retrospective study of secondary data from eight Directly Observed Treatment Short (DOTS) course and Anti- Retroviral Therapy (ART) service providers in Benue and Federal Capital Territory (FCT), Nigeria, was carried out. The period under review covers January, 2010 to December, 2013. Results: Out of the total 5266 TB cases reviewed, the HIV prevalence rate was 52%. They were predominantly (53.3%) male with mean age of 34.4 years (SD = 15.1 years). More than two-third (72.5%) of HIV-negative patients had successful treatment compared to 1718 (62.7%) HIV-positive patients. Of the 2334 HIV co-infected patients, 19.5% defaulted, 11.5% had died, 5.6% were transferred out and 0.7% failed treatment compared to HIV-negative patients amongst whom 18.3% defaulted, 3.6% died, 3.9% were transferred out and 1.6% failed treatment (p Conclusion: The favourable treatment outcome of HIV-negative patients is more than that of HIV-positive patients and the most probable predictable factor responsible is the CD4 count of patient;indicating that TB/HIV co-infection has remained a major public health problem in Benue state and FCT. Hence there is the need for sustained strengthening and expansion of the national TB/HIV programmes.

关 键 词：TUBERCULOSIS Treatment Outcomes TB/HIV CO-INFECTION DOTS 

分 类 号：R51[医药卫生—内科学]