Indications, Interpretation and Clinical Consequences of Tuberculin Skin Tests in Resource Limited Settings  

作　　者：Fitzgerald A. Gopie Aabidien Hassankhan Wilco C. W. R. Zijlmans Stephen G. S. Vreden Fitzgerald A. Gopie;Aabidien Hassankhan;Wilco C. W. R. Zijlmans;Stephen G. S. Vreden(Faculty of Medical Sciences, Anton de Kom University of Suriname, Paramaribo, Suriname;Academic Hospital Paramaribo, Paramaribo, Suriname;MoleMann Mental Health Suriname, Paramaribo, Suriname;Department of Paediatrics, Diakonessenhuis Hospital, Paramaribo, Suriname;Department of Internal Medicine, Academic Hospital Paramaribo, Paramaribo, Suriname)

机构地区：[1]Faculty of Medical Sciences, Anton de Kom University of Suriname, Paramaribo, Suriname [2]Academic Hospital Paramaribo, Paramaribo, Suriname [3]MoleMann Mental Health Suriname, Paramaribo, Suriname [4]Department of Paediatrics, Diakonessenhuis Hospital, Paramaribo, Suriname [5]Department of Internal Medicine, Academic Hospital Paramaribo, Paramaribo, Suriname

出　　处：《Journal of Tuberculosis Research》2021年第3期172-183,共12页结核病研究（英文）

摘　　要：<b><span style="font-family:Verdana;">Objective:</span></b><span style="font-family:Verdana;"></span><b> </b><span style="font-family:Verdana;">to evaluate the policy of TST testing in Suriname. As there is no gold standard to diagnose latent tuberculosis infection (LTBI), the tuberculin skin test (TST) is used to diagnose LTBI. However, internationally, the cut-off values of the TST are not uniform and depend on local tuberculosis (TB) epidemiology and guidelines for test initiation. In Suriname, where currently several indications exist for TSTs, cut-off values are set at 5 mm or 10 mm, depending on the age and/or medical history of the patient. LTBI classification is performed by pulmonologists primarily based on the American Thoracic Society targeted TB testing guidelines. <b></b></span><b><b><span style="font-family:Verdana;">Method:</span></b><span style="font-family:Verdana;"></span></b><b> </b><span style="font-family:Verdana;">retrospective analysis of outpatient TST data between 2011 and 2019 from Suriname’s sole pulmonary medicine clinic. <b></b></span><b><b><span style="font-family:Verdana;">Result:</span></b><span></span></b><span style="font-family:Verdana;"> 1373 patients were evaluated. 590 patients were from the screening group of whom 253 had a positive TST result, 46 of whom were classified as LTBI. In the contact tracing group of 649 patients, 616 had a positive TST, 352 of whom were classified as LTBI. In the medical condition group of 134 patients, 96 had a positive TST, 38 of whom were classified as LTBI. Eventually, positive TST results were found for 965 tested patients: 436 patients were classified as LTBI and 529 non-LTBI patients were not prescribed chemoprophylaxis. None of the non-LTBI TST-positive patients were diagnosed with active TB, including 174 patients with a TST result of 15 mm or greater and in need of IPT, but not prescribed by jud</span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">g</span></span></span><span><s<b><span style="font-family:Verdana;">Objective:</span></b><span style="font-family:Verdana;"></span><b> </b><span style="font-family:Verdana;">to evaluate the policy of TST testing in Suriname. As there is no gold standard to diagnose latent tuberculosis infection (LTBI), the tuberculin skin test (TST) is used to diagnose LTBI. However, internationally, the cut-off values of the TST are not uniform and depend on local tuberculosis (TB) epidemiology and guidelines for test initiation. In Suriname, where currently several indications exist for TSTs, cut-off values are set at 5 mm or 10 mm, depending on the age and/or medical history of the patient. LTBI classification is performed by pulmonologists primarily based on the American Thoracic Society targeted TB testing guidelines. <b></b></span><b><b><span style="font-family:Verdana;">Method:</span></b><span style="font-family:Verdana;"></span></b><b> </b><span style="font-family:Verdana;">retrospective analysis of outpatient TST data between 2011 and 2019 from Suriname’s sole pulmonary medicine clinic. <b></b></span><b><b><span style="font-family:Verdana;">Result:</span></b><span></span></b><span style="font-family:Verdana;"> 1373 patients were evaluated. 590 patients were from the screening group of whom 253 had a positive TST result, 46 of whom were classified as LTBI. In the contact tracing group of 649 patients, 616 had a positive TST, 352 of whom were classified as LTBI. In the medical condition group of 134 patients, 96 had a positive TST, 38 of whom were classified as LTBI. Eventually, positive TST results were found for 965 tested patients: 436 patients were classified as LTBI and 529 non-LTBI patients were not prescribed chemoprophylaxis. None of the non-LTBI TST-positive patients were diagnosed with active TB, including 174 patients with a TST result of 15 mm or greater and in need of IPT, but not prescribed by jud</span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">g</span></span></span><span><s

关 键 词：Tuberculin Skin Test Cut-Off Values Guidelines REVISION 

分 类 号：R65[医药卫生—外科学]