Impact of a Mass Campaign on the Evolution of the Fourth Wave of the Covid-19 Pandemic in the Central African Republic  

作　　者：Clotaire Donatien Rafaï Pierre Somse Wilfrid Sylvain Nambei Ernest Lango-Yaya Marie-Roseline Darnycka Belizaire Ulrich Vickos Narcisse Patrice Komas Oscar Senzongo Luc Salva Heredeibona Ulrich Jeffrey Kotemossoua Rabbi Mermoz Senekian Simon Pounguinza Jephté Estimé Kaleb Christian-Diamant Mossoro-Kpinde Alain Le Faou Jean De Dieu Longo Norbert Richard Ngbale Abdoulaye Sepou François-Xavier Mbopi-Keou Gérard Grésenguet Boniface Koffi Clotaire Donatien Rafaï;Pierre Somse;Wilfrid Sylvain Nambei;Ernest Lango-Yaya;Marie-Roseline Darnycka Belizaire;Ulrich Vickos;Narcisse Patrice Komas;Oscar Senzongo;Luc Salva Heredeibona;Ulrich Jeffrey Kotemossoua;Rabbi Mermoz Senekian;Simon Pounguinza;Jephté Estimé Kaleb;Christian-Diamant Mossoro-Kpinde;Alain Le Faou;Jean De Dieu Longo;Norbert Richard Ngbale;Abdoulaye Sepou;François-Xavier Mbopi-Keou;Gérard Grésenguet;Boniface Koffi(National Laboratory of Clinical Biology and Public Health, Bangui, Central African Republic;Faculty of Health Sciences, University of Bangui, Bangui, Central African Republic;Ministry of Health and Population, Bangui, Central African Republic;World Health Organization, Bangui, Central African Republic;Pasteur Institute of Bangui, Bangui, Central African Republic;Faculty of Medicine, Midwifery and Health Professions, University of Lorraine, Nancy, France;Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroun;Community University Hospital Center of Bangui, Bangui, Central African Republic)

机构地区：[1]National Laboratory of Clinical Biology and Public Health, Bangui, Central African Republic [2]Faculty of Health Sciences, University of Bangui, Bangui, Central African Republic [3]Ministry of Health and Population, Bangui, Central African Republic [4]World Health Organization, Bangui, Central African Republic [5]Pasteur Institute of Bangui, Bangui, Central African Republic [6]Faculty of Medicine, Midwifery and Health Professions, University of Lorraine, Nancy, France [7]Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroun [8]Community University Hospital Center of Bangui, Bangui, Central African Republic

出　　处：《Journal of Tuberculosis Research》2024年第3期142-150,共9页结核病研究（英文）

摘　　要：Objective: In the context of increasing cases despite vaccination campaigns, a survey was conducted in the Bangui population from January 17 to 26, 2022, to evaluate the strains of Severe Acute Respiratory Infection Coronavirus 2 (SARS-Cov-2) circulating in a healthy population. Materials and methods: This study was conducted by taking nasopharyngeal samples from randomly selected volunteers. Antigen detection was performed systematically, and RT-PCR was done on the positive samples. Results and discussion: We collected 2,554 samples. Thirty were found RT-PCR positive (1.2%) and sent for viral genome sequencing. Twenty-eight SARS-Cov-2 strains belonged to the Omicron type, and only 2 to the Delta type. Conclusion: Thus, infections were uncommon in the tested population, but the presence of Omicron and Delta types raises concerns that vaccination may not be effective in fighting the virus, and newly designed vaccines should be implemented to better protect the population at risk of infection and reinfection by these variants.Objective: In the context of increasing cases despite vaccination campaigns, a survey was conducted in the Bangui population from January 17 to 26, 2022, to evaluate the strains of Severe Acute Respiratory Infection Coronavirus 2 (SARS-Cov-2) circulating in a healthy population. Materials and methods: This study was conducted by taking nasopharyngeal samples from randomly selected volunteers. Antigen detection was performed systematically, and RT-PCR was done on the positive samples. Results and discussion: We collected 2,554 samples. Thirty were found RT-PCR positive (1.2%) and sent for viral genome sequencing. Twenty-eight SARS-Cov-2 strains belonged to the Omicron type, and only 2 to the Delta type. Conclusion: Thus, infections were uncommon in the tested population, but the presence of Omicron and Delta types raises concerns that vaccination may not be effective in fighting the virus, and newly designed vaccines should be implemented to better protect the population at risk of infection and reinfection by these variants.

关 键 词：COVID-19 SARS-CoV-2 Variants 

分 类 号：R37[医药卫生—病原生物学]