Examination of Urinary Chlorpyrifos Biomarker Concentrations and Heart Rate in a Sample of US Children and Adolescents  

作　　者：Alex LeBeau Desirae Sutherland Marie Bourgeois Jeffrey Driver Raymond Harbison Alex LeBeau;Desirae Sutherland;Marie Bourgeois;Jeffrey Driver;Raymond Harbison(Center for Environmental and Occupational Risk Analysis and Management, College of Public Health, University of South Florida, Tampa, Florida, USA)

机构地区：[1]Center for Environmental and Occupational Risk Analysis and Management, College of Public Health, University of South Florida, Tampa, Florida, USA

出　　处：《Occupational Diseases and Environmental Medicine》2020年第4期163-174,共12页职业病与环境医学（英文）

摘　　要：<strong>Objective:</strong> The purpose of the investigation is to determine if a relationship exists between heart rate and urinary biomarkers of chronic, subacute chlorpyrifos pesticide exposure in youth. <strong>Methods:</strong> Using 2001-2002 NHANES data, a sample of 1233 children ages 6 - 18 was grouped based on detection status of 3,5,6-trichloropyridinol (TCPy) in urine. Radial pulse and brachial pulse were recorded as measures of heart rate by physicians. <em>T</em>-tests and linear regression analyses were performed to test for associations between TCPy concentrations and heart rate. <strong>Results:</strong> None of the associations between TCPy levels and heart rate outcomes were found to be significant. Nonsignificant effects in the TCPy-detected groups included a slightly reduced heart rate in girls, as well as a slightly elevated heart rate in boys when compared to the undetected controls. Neither was there any significant observable difference in heart rate due to detection status in the sample overall. <strong>Conclusions:</strong> At this time, an effect on heart rate attributable to chronic, low-level chlorpyrifos exposure in youth cannot be determined. Children and adolescents detected did not demonstrate a substantial change in pulse measures when compared to controls. It is recommended that subsequent studies examine chlorpyrifos biomarkers as they may relate to other indicators of cardiovascular health.<strong>Objective:</strong> The purpose of the investigation is to determine if a relationship exists between heart rate and urinary biomarkers of chronic, subacute chlorpyrifos pesticide exposure in youth. <strong>Methods:</strong> Using 2001-2002 NHANES data, a sample of 1233 children ages 6 - 18 was grouped based on detection status of 3,5,6-trichloropyridinol (TCPy) in urine. Radial pulse and brachial pulse were recorded as measures of heart rate by physicians. <em>T</em>-tests and linear regression analyses were performed to test for associations between TCPy concentrations and heart rate. <strong>Results:</strong> None of the associations between TCPy levels and heart rate outcomes were found to be significant. Nonsignificant effects in the TCPy-detected groups included a slightly reduced heart rate in girls, as well as a slightly elevated heart rate in boys when compared to the undetected controls. Neither was there any significant observable difference in heart rate due to detection status in the sample overall. <strong>Conclusions:</strong> At this time, an effect on heart rate attributable to chronic, low-level chlorpyrifos exposure in youth cannot be determined. Children and adolescents detected did not demonstrate a substantial change in pulse measures when compared to controls. It is recommended that subsequent studies examine chlorpyrifos biomarkers as they may relate to other indicators of cardiovascular health.

关 键 词：CHLORPYRIFOS Organophosphates PESTICIDES Acetylcholinesterase Inhibitors TCPy Heart Rate Pulse CARDIOVASCULAR Exposure Urinary Metabolites Children YOUTH Adolescents 

分 类 号：S48[农业科学—农药学]