Effect of Magnesium Sulfate Nebulization on Stress Response Induced Tracheal Intubation;Prospective, Randomized Study  

作　　者：Mohamed Said Mostafa Elmeligy Mohamed Fouad Mohamed Elmeliegy Mohamed Said Mostafa Elmeligy;Mohamed Fouad Mohamed Elmeliegy(Anaesthesia Department, Benha University, Benha, Egypt)

机构地区：[1]Anaesthesia Department, Benha University, Benha, Egypt

出　　处：《Open Journal of Anesthesiology》2021年第4期128-135,共8页麻醉学期刊（英文）

摘　　要：<b>Background and Aims:</b> Multiple, nonpharmacological and pharmacological measures have been used for attenuating stress response of intubation with variable results. N-methyl-D-aspartate (NMDA) receptors have a role in nociception and inflammation. NMDA receptors are located in peripheral and the central nervous system. Magnesium is also a NMDA receptor blocker. <b>Aim of the Study:</b> To evaluate the effect of nebulized magnesium sulfate on reduce the stress response induced tracheal intubation <b>Material and Methods:</b> Following institutional ethical committee approval and written informed consent, a prospective randomized double-blinded study was conducted in 100 cases divided into two equal groups. Patients included in the study were of either gender belonging to American Society of Anesthesiologists (ASA) status 1 or 2 undergoing elective surgery requiring tracheal intubation. Patients will be recruited in the study divided into two equal groups;Patients in Group A: will receive nebulized magnesium sulfate in 3 ml (240 mg) over 15 min. While group B: will receive nebulized normal saline in 3 ml over 15 min, ending 5 min before the induction of anesthesia. SBP, DBP, HR, and blood glucose level will be measured at the following intervals;Baseline (before induction), after premedication (sedation), after induction, after ETT intubation, 3 min later, 6 min later. <b>Results:</b> Preoperative magnesium sulfate nebulization has a significant effect (p value < 0.001) on attenuating the stress response (SBP, DBP, HR, and SBG) to tracheal intubation at the following intervals;post ETT intubation, 3 min later, and 6 min later. <b>Conclusion:</b> Magnesium sulfate significantly reduces the stress response of intubation.<b>Background and Aims:</b> Multiple, nonpharmacological and pharmacological measures have been used for attenuating stress response of intubation with variable results. N-methyl-D-aspartate (NMDA) receptors have a role in nociception and inflammation. NMDA receptors are located in peripheral and the central nervous system. Magnesium is also a NMDA receptor blocker. <b>Aim of the Study:</b> To evaluate the effect of nebulized magnesium sulfate on reduce the stress response induced tracheal intubation <b>Material and Methods:</b> Following institutional ethical committee approval and written informed consent, a prospective randomized double-blinded study was conducted in 100 cases divided into two equal groups. Patients included in the study were of either gender belonging to American Society of Anesthesiologists (ASA) status 1 or 2 undergoing elective surgery requiring tracheal intubation. Patients will be recruited in the study divided into two equal groups;Patients in Group A: will receive nebulized magnesium sulfate in 3 ml (240 mg) over 15 min. While group B: will receive nebulized normal saline in 3 ml over 15 min, ending 5 min before the induction of anesthesia. SBP, DBP, HR, and blood glucose level will be measured at the following intervals;Baseline (before induction), after premedication (sedation), after induction, after ETT intubation, 3 min later, 6 min later. <b>Results:</b> Preoperative magnesium sulfate nebulization has a significant effect (p value < 0.001) on attenuating the stress response (SBP, DBP, HR, and SBG) to tracheal intubation at the following intervals;post ETT intubation, 3 min later, and 6 min later. <b>Conclusion:</b> Magnesium sulfate significantly reduces the stress response of intubation.

关 键 词：MAGNESIUM INTUBATION 

分 类 号：R61[医药卫生—外科学]