The Pattern of Haematological Changes in the Baseline Blood Cell Counts and the CD4⁺T Lymphocyte Levels among Antiretroviral Therapy Naïve Adult HIV Positive Patients in a Nigerian Hospital  

作　　者：Taiwo Modupe Balogun Abiola Omosalewa Alao Olawunmi Femi Olaosebikan Adewunmi James Aremu Oladunni Olajumoke Adegbite Taiwo Modupe Balogun;Abiola Omosalewa Alao;Olawunmi Femi Olaosebikan;Adewunmi James Aremu;Oladunni Olajumoke Adegbite(Department of Haematology and Blood Transfusion, Igbinedion University, Okada, Edo State, Nigeria;HIV Laboratory, HIV Clinics, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria)

机构地区：[1]Department of Haematology and Blood Transfusion, Igbinedion University, Okada, Edo State, Nigeria [2]HIV Laboratory, HIV Clinics, Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria

出　　处：《Open Journal of Blood Diseases》2020年第3期77-88,共12页血液病期刊（英文）

摘　　要：<b><span style="font-family:Verdana;">Background: </span></b><span style="font-family:Verdana;">Haematological abnormalities are strong independent predictors of morbidity and mortality in HIV infection.</span><span style="font-family:;" "=""> </span><b><span style="font-family:Verdana;">Objectives of the Study:</span></b><span style="font-family:Verdana;"> This study was carried out to assess the pattern of the changes in the baseline peripheral blood cell counts among adult HIV positive patients. To also determine the </span><span style="font-family:;" "=""><span style="font-family:Verdana;">CD4</span>^{<span style="font-family:Verdana;">+</span>}</span><span style="font-family:Verdana;"> T</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cell levels and its correlation with the changes in the baseline cell counts of the patients using HIV negative blood donors as controls.</span><span style="font-family:;" "=""> </span><b><span style="font-family:Verdana;">Methods</span></b><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"> This was a case controlled prospective study. The subjects were antiretroviral therapy naive adult HIV positive patients and HIV negative blood donor controls. Five milliliters (5</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">mls) of venous blood was collected from the cubitus of every consecutive consenting subject. Blood sample was analysed for baseline complete blood cell counts and the </span><span style="font-family:;" "=""><span style="font-family:Verdana;">CD4</span>^{<span style="font-family:Verdana;">+</span>}</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">T lymphocyte levels using Sysmex and Cyflow R Counter autoanalysers respectively. Obtained data was analysed with the statistical package for the social scientist (SPSS version 20.0). The Erythrocyte sedimentation rate of subjects was measured b<b><span style="font-family:Verdana;">Background: </span></b><span style="font-family:Verdana;">Haematological abnormalities are strong independent predictors of morbidity and mortality in HIV infection.</span><span style="font-family:;" "=""> </span><b><span style="font-family:Verdana;">Objectives of the Study:</span></b><span style="font-family:Verdana;"> This study was carried out to assess the pattern of the changes in the baseline peripheral blood cell counts among adult HIV positive patients. To also determine the </span><span style="font-family:;" "=""><span style="font-family:Verdana;">CD4</span>^{<span style="font-family:Verdana;">+</span>}</span><span style="font-family:Verdana;"> T</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">cell levels and its correlation with the changes in the baseline cell counts of the patients using HIV negative blood donors as controls.</span><span style="font-family:;" "=""> </span><b><span style="font-family:Verdana;">Methods</span></b><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"> This was a case controlled prospective study. The subjects were antiretroviral therapy naive adult HIV positive patients and HIV negative blood donor controls. Five milliliters (5</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">mls) of venous blood was collected from the cubitus of every consecutive consenting subject. Blood sample was analysed for baseline complete blood cell counts and the </span><span style="font-family:;" "=""><span style="font-family:Verdana;">CD4</span>^{<span style="font-family:Verdana;">+</span>}</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">T lymphocyte levels using Sysmex and Cyflow R Counter autoanalysers respectively. Obtained data was analysed with the statistical package for the social scientist (SPSS version 20.0). The Erythrocyte sedimentation rate of subjects was measured b

关 键 词：HAEMATOLOGY COMPLICATIONS HIV Infection NIGERIA 

分 类 号：O17[理学—数学]