Hemostasis Efficacy and Mechanism of Cold Atmospheric Air Plasma  

作　　者：Spencer Kuo Spencer Kuo(Department of Electrical & Computer Engineering, New York University-Tandon School of Engineering, Brooklyn, USA)

机构地区：[1]Department of Electrical & Computer Engineering, New York University-Tandon School of Engineering, Brooklyn, USA

出　　处：《Open Journal of Emergency Medicine》2021年第3期66-83,共18页急诊医学（英文）

摘　　要：<span style="font-family:Verdana;">The capacity of a cold atmospheric-pressure air plasma (CAAP) device for advanced first aid is presented. Using swine as </span><span style="font-family:Verdana;">an </span><span style="font-family:Verdana;">animal model, two trials: 1) a large, curved cut in hindquarters area and 2)</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">amputation of a front leg, were perfo</span><span style="font-family:Verdana;">rmed. Cold atmospheric-pressure air plasma effluent, which carri</span><span style="font-family:Verdana;">es reactive oxygen species (ROS) atomic oxygen (OI), is applied for wound treatments. Swift hemostasis of the wounds by the CAAP treatment was demonstrated. The pressure applied by a finger on the cut arteries in trial 1 and the tourniquet applied in trial 2 could be removed immediately after the treatment and there was no re-bleed in both cases. CAAP hemostasis mechanism wa</span><span><span style="font-family:Verdana;">s explored via </span><i><span style="font-family:Verdana;">in</span></i><span style="font-family:Verdana;">-</span><i><span style="font-family:Verdana;">vitro</span></i><span style="font-family:Verdana;"> tests. The tests on sodium citrate mix</span></span><span style="font-family:Verdana;">ed blood-droplet samples show that 1) the heat delivered by the CAAP has no impact on the observed clot formation, 2) plasma effluent activates platelets to promote coagulation state and cascade, and 3) the degree of clotting increases with the total amount of applied OI by means of the CAAP effluent. It took only 16 s o</span><span style="font-family:Verdana;">f the CAAP treatment to reach full clotting, which was considerab</span><span style="font-family:Verdana;">ly shorten</span><span style="font-family:Verdana;">ed from the natural clotting time of about 25 minutes. The tests on</span><span style="font-family:Verdana;"> smeared blood samples show that the reduction of the platelet count and the increase of<span style="font-family:Verdana;">The capacity of a cold atmospheric-pressure air plasma (CAAP) device for advanced first aid is presented. Using swine as </span><span style="font-family:Verdana;">an </span><span style="font-family:Verdana;">animal model, two trials: 1) a large, curved cut in hindquarters area and 2)</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">amputation of a front leg, were perfo</span><span style="font-family:Verdana;">rmed. Cold atmospheric-pressure air plasma effluent, which carri</span><span style="font-family:Verdana;">es reactive oxygen species (ROS) atomic oxygen (OI), is applied for wound treatments. Swift hemostasis of the wounds by the CAAP treatment was demonstrated. The pressure applied by a finger on the cut arteries in trial 1 and the tourniquet applied in trial 2 could be removed immediately after the treatment and there was no re-bleed in both cases. CAAP hemostasis mechanism wa</span><span><span style="font-family:Verdana;">s explored via </span><i><span style="font-family:Verdana;">in</span></i><span style="font-family:Verdana;">-</span><i><span style="font-family:Verdana;">vitro</span></i><span style="font-family:Verdana;"> tests. The tests on sodium citrate mix</span></span><span style="font-family:Verdana;">ed blood-droplet samples show that 1) the heat delivered by the CAAP has no impact on the observed clot formation, 2) plasma effluent activates platelets to promote coagulation state and cascade, and 3) the degree of clotting increases with the total amount of applied OI by means of the CAAP effluent. It took only 16 s o</span><span style="font-family:Verdana;">f the CAAP treatment to reach full clotting, which was considerab</span><span style="font-family:Verdana;">ly shorten</span><span style="font-family:Verdana;">ed from the natural clotting time of about 25 minutes. The tests on</span><span style="font-family:Verdana;"> smeared blood samples show that the reduction of the platelet count and the increase of

关 键 词：Cold Atmospheric Air Plasma Cold Atmospheric Plasma Reactive Species Reactive Oxygen Species Atomic Oxygen TRAUMA HEMORRHAGE HEMOSTASIS Animal Model Swine Blood Coagulation CLOTTING 

分 类 号：O17[理学—数学]