Losartan Induced Angioedema, a Rare Case Report and the Dilemma of Using Angiotensin II Receptor Blockers in Patients with Previous Angioedema with Angiotensin Converting Enzyme Inhibitors  

作　　者：Sayani Banerjee Abdul Sajjad Pathan Sayani Banerjee;Abdul Sajjad Pathan(Department of Emergency Medicine, Weston General Hospital, University of Bristol & Weston, NHS Foundation Trust, Weston Super Mare, UK;Department of Emergency Medicine, Royal Surrey NHS Foundation Trust, Guilford, UK)

机构地区：[1]Department of Emergency Medicine, Weston General Hospital, University of Bristol & Weston, NHS Foundation Trust, Weston Super Mare, UK [2]Department of Emergency Medicine, Royal Surrey NHS Foundation Trust, Guilford, UK

出　　处：《Open Journal of Emergency Medicine》2024年第3期69-76,共8页急诊医学（英文）

摘　　要：Angiotensin Receptor Blockers (ARB) are used as an alternative of Angiotensin Converting Enzyme Inhibitors (ACEI) in patients where ACEIs cannot be used because of their known adverse effects, cough and angioedema. Thus ARB induced angioedema is considered to be a rare phenomenon and it is continued to be used as an alternatives of ACEIs. In this case report, we reported a case of 78-year-old gentleman who presented to emergency department with losartan, an ARB induced angioedema, who did not have history of any previous use of ACEIs. He was given steroids and antihistamine as a treatment. His angioedema resolved rapidly and he was discharged after six hours of emergency department (ED) observation with stable hemodynamically. We, the authors by reporting this case, wants to make clinicians aware ARB, however rarely, can cause angioedema, which can be life threatening if clinicians are not aware of it and diagnose and stop the offending drug promptly and treat it early.Angiotensin Receptor Blockers (ARB) are used as an alternative of Angiotensin Converting Enzyme Inhibitors (ACEI) in patients where ACEIs cannot be used because of their known adverse effects, cough and angioedema. Thus ARB induced angioedema is considered to be a rare phenomenon and it is continued to be used as an alternatives of ACEIs. In this case report, we reported a case of 78-year-old gentleman who presented to emergency department with losartan, an ARB induced angioedema, who did not have history of any previous use of ACEIs. He was given steroids and antihistamine as a treatment. His angioedema resolved rapidly and he was discharged after six hours of emergency department (ED) observation with stable hemodynamically. We, the authors by reporting this case, wants to make clinicians aware ARB, however rarely, can cause angioedema, which can be life threatening if clinicians are not aware of it and diagnose and stop the offending drug promptly and treat it early.

关 键 词：ANGIOEDEMA Airway Emergency Acute Presentation 

分 类 号：R54[医药卫生—心血管疾病]