A Review of Endocrine Disorders in Thalassaemia  

作　　者：Parijat De Radhika Mistry Christine Wright Shivan Pancham Wyn Burbridge Kalyan Gangopadhayay Terence Pang Gautam Das 

机构地区：[1]Department of Diabetes and Endocrinology, Southern General Hospital, Glasgow, UK [2]Department of Diabetes, Endocrinology and Lipid Metabolism, City Hospital, Birmingham, UK [3]Sickle Cell and Thalassaemia Unit, City Hospital, Birmingham, UK

出　　处：《Open Journal of Endocrine and Metabolic Diseases》2014年第2期25-34,共10页内分泌与新陈代谢疾病期刊（英文）

摘　　要：Endocrine dysfunction in thalassaemia is amongst the most common complication and is principally attributed to excessive iron overload and suboptimal chelation. The prevalence is quite high particularly in multiethnic populations but determining the prevalence is often difficult due to the widespread heterogeneity of the population and timing of exposure to chelation therapy. Disturbances in growth, pubertal development, abnormal gonadal functions, impaired thyroid, parathyroid and adrenal functions, diabetes and disorderly bone growth are commonly encountered. Early detection and institution of appropriate transfusion regimen and chelation therapy and treatment of complications are the keys to managing this population including regular follow. In this article, we review the literature in relation to the various endocrine complications encountered in thalassaemia.Endocrine dysfunction in thalassaemia is amongst the most common complication and is principally attributed to excessive iron overload and suboptimal chelation. The prevalence is quite high particularly in multiethnic populations but determining the prevalence is often difficult due to the widespread heterogeneity of the population and timing of exposure to chelation therapy. Disturbances in growth, pubertal development, abnormal gonadal functions, impaired thyroid, parathyroid and adrenal functions, diabetes and disorderly bone growth are commonly encountered. Early detection and institution of appropriate transfusion regimen and chelation therapy and treatment of complications are the keys to managing this population including regular follow. In this article, we review the literature in relation to the various endocrine complications encountered in thalassaemia.

关 键 词：THALASSAEMIA CHELATION Endocrinopathies DIABETES HYPOTHYROIDISM 

分 类 号：R5[医药卫生—内科学]