Evaluation of Plasma Malondialdehyde among Sudanese Type 2 Diabetic Patients  

作　　者：Gad Allah Modawe Ibtihal Elamin Mohammed Abuagla M. Dafalla Abdelmarouf Mohieldein Gad Allah Modawe;Ibtihal Elamin Mohammed;Abuagla M. Dafalla;Abdelmarouf Mohieldein(Faculty of Medicine and Health Sciences, Department of Biochemistry, Omdurman Islamic University, Omdurman, Sudan;Medical Laboratory Sciences, Department of Clinical Chemistry, National University, Khartoum, Sudan;Faculty of Medical Laboratory Sciences, Department of Clinical Chemistry, University of Gezira, WadMadani, Sudan;College of Applied Medical Sciences, Department of Medical Laboratories, Qassim University, Buraidah, Kingdom of Saudi Arabia)

机构地区：[1]Faculty of Medicine and Health Sciences, Department of Biochemistry, Omdurman Islamic University, Omdurman, Sudan [2]Medical Laboratory Sciences, Department of Clinical Chemistry, National University, Khartoum, Sudan [3]Faculty of Medical Laboratory Sciences, Department of Clinical Chemistry, University of Gezira, WadMadani, Sudan [4]College of Applied Medical Sciences, Department of Medical Laboratories, Qassim University, Buraidah, Kingdom of Saudi Arabia

出　　处：《Open Journal of Endocrine and Metabolic Diseases》2023年第12期234-243,共10页内分泌与新陈代谢疾病期刊（英文）

摘　　要：Background and objectives: Diabetes is a chronic multifactorial disease which requires a variety of strategies to reduce its epidemic. Type 2 diabetes (T2MD) is the most common form of diabetes which results from inefficiency of insulin secretion or resistance to insulin action, both of which lead to chronic hyperglycemia. Lipid peroxidation is an oxidative stress process that involve in T2DM complications. This study aimed to 1) determine plasma malondialdehyde (MDA) levels as a biomarker for lipid peroxidation in Sudanese patients with T2DM, and 2) assess the associations between MDA and diabetes-related variables. Material and Methods: This case-control study was conducted from November 2022 to June 2023 at the National University, Sudan. It included 100 participants, of whom 50 were T2DM patients and 50 were healthy controls. Data on demographics, clinical characteristics, and biochemical markers (FBS, HbA1c, and MDA) were collected. The NycoCard HbA1c method and the GOD-POD Method were used for HbA1c and glucose measurement, respectively. MDA was determined by the thiobarbituric acid reactive substances method. The data were analyzed using SPSS Version. Results: Significant differences were observed between T2DM patients and healthy controls in FBS (P = 0.000), HbA1c (P = 0.000), and MDA (P = 0.010), with T2DM patients exhibiting higher levels. The study revealed a strong positive correlation between MDA levels and the duration of diabetes (r = 0.69, P = 0.00), while other variables, including age, BMI, and glucose control, did not significantly correlate with MDA levels. Conclusion: Findings revealed elevated MDA levels in Sudanese T2DM patients, with a positive correlation between MDA and diabetes duration. These findings emphasize the importance of oxidative stress in T2DM pathogenesis and call for the need for targeted strategies to mitigate oxidative damage and improve diabetes care.Background and objectives: Diabetes is a chronic multifactorial disease which requires a variety of strategies to reduce its epidemic. Type 2 diabetes (T2MD) is the most common form of diabetes which results from inefficiency of insulin secretion or resistance to insulin action, both of which lead to chronic hyperglycemia. Lipid peroxidation is an oxidative stress process that involve in T2DM complications. This study aimed to 1) determine plasma malondialdehyde (MDA) levels as a biomarker for lipid peroxidation in Sudanese patients with T2DM, and 2) assess the associations between MDA and diabetes-related variables. Material and Methods: This case-control study was conducted from November 2022 to June 2023 at the National University, Sudan. It included 100 participants, of whom 50 were T2DM patients and 50 were healthy controls. Data on demographics, clinical characteristics, and biochemical markers (FBS, HbA1c, and MDA) were collected. The NycoCard HbA1c method and the GOD-POD Method were used for HbA1c and glucose measurement, respectively. MDA was determined by the thiobarbituric acid reactive substances method. The data were analyzed using SPSS Version. Results: Significant differences were observed between T2DM patients and healthy controls in FBS (P = 0.000), HbA1c (P = 0.000), and MDA (P = 0.010), with T2DM patients exhibiting higher levels. The study revealed a strong positive correlation between MDA levels and the duration of diabetes (r = 0.69, P = 0.00), while other variables, including age, BMI, and glucose control, did not significantly correlate with MDA levels. Conclusion: Findings revealed elevated MDA levels in Sudanese T2DM patients, with a positive correlation between MDA and diabetes duration. These findings emphasize the importance of oxidative stress in T2DM pathogenesis and call for the need for targeted strategies to mitigate oxidative damage and improve diabetes care.

关 键 词：Lipid Peroxide MALONDIALDEHYDE HYPERGLYCEMIA Type 2 Diabetes Mellitus SUDANESE 

分 类 号：R58[医药卫生—内分泌]