Hepatitis C: Epidemiological, Clinical and Therapeutic Aspects in Dakar (Senegal)  

作　　者：Salamata Diallo Mariéme Polele Fall Marie Louise Bassène Mamadou Ngoné Gueye Mame Aissé Thioubou Cheikh Ahmadou Bamba Cissé Alioune Badara Fall Abdoul Aziz Atteib Fall Alsine Yauck Salamata Diallo;Mariéme Polele Fall;Marie Louise Bassène;Mamadou Ngoné Gueye;Mame Aissé Thioubou;Cheikh Ahmadou Bamba Cissé;Alioune Badara Fall;Abdoul Aziz Atteib Fall;Alsine Yauck(Cheikh Anta Diop University of Dakar, Hospital Aristide Le Dantec, Dakar, Senegal;Cheikh Anta Diop University of Dakar, Hospital Idrissa Pouye, Dakar, Senegal;Assane Seck University of Ziguinchor, Hospital de la Paix, Ziguinchor, Senegal)

机构地区：[1]Cheikh Anta Diop University of Dakar, Hospital Aristide Le Dantec, Dakar, Senegal [2]Cheikh Anta Diop University of Dakar, Hospital Idrissa Pouye, Dakar, Senegal [3]Assane Seck University of Ziguinchor, Hospital de la Paix, Ziguinchor, Senegal

出　　处：《Open Journal of Gastroenterology》2022年第4期98-106,共9页肠胃病学期刊（英文）

摘　　要：Viral hepatitis C is a major public health problem. The aim of our work was to determine the epidemiological, diagnostic and treatment profiles of patients with HCV in Dakar (Senegal). We conducted a retrospective, descriptive, multicentre study between January 1, 2010, and December 31, 2019. We included 26 patients. The mean age of the patients was 53.5 years [28 - 70 years] and 46.2% were males. Of the 26 patients included, 7 (26.9%) were Senegalese, and the majority were from other African countries. Risk factors for contamination found were surgery in 11 patients (42.3%) and blood transfusion in 1 patient (3.8%). The mean viral load was 6.47 log IU/ml [4.26 - 7.26 log IU/ml]. Ten patients were infected by genotype 4. No patients were co-infected with HIV or HBV. Six patients (23.1% of patients) had significant fibrosis, of which five (19.2% of patients) were in the stage of cirrhosis. Twelve patients (46.2%) started treatment. Eleven were treatment-naïve and 1 did not respond to ribavirin-pegylated interferon-based therapy after 48 weeks. Ten cases of antiviral therapy were based on DAA and ribavirin-pegylated interferon in 2 patients. For the patients treated with peginterferon and ribavirin, a rapid virologic response was observed at 12 weeks in one patient, and the other patient was lost to follow-up. Among DAA-treated patients, 7 had sustained virologic responses at 12 weeks, 2 persisted, and 1 was lost to follow-up. Moderate thrombocytopenia and weight loss were observed in one patient receiving peginterferon and ribavirin. In our study, no patient died on treatment and no patients developed de novo HCC during or after DAA therapy. Conclusion: Viral hepatitis C is rare in Senegal. Despite the progress made in the therapeutic management of viral hepatitis C, it remains a challenge in Senegal. Indeed, DAAs are expensive and are not marketed, which makes them inaccessible to most patients.Viral hepatitis C is a major public health problem. The aim of our work was to determine the epidemiological, diagnostic and treatment profiles of patients with HCV in Dakar (Senegal). We conducted a retrospective, descriptive, multicentre study between January 1, 2010, and December 31, 2019. We included 26 patients. The mean age of the patients was 53.5 years [28 - 70 years] and 46.2% were males. Of the 26 patients included, 7 (26.9%) were Senegalese, and the majority were from other African countries. Risk factors for contamination found were surgery in 11 patients (42.3%) and blood transfusion in 1 patient (3.8%). The mean viral load was 6.47 log IU/ml [4.26 - 7.26 log IU/ml]. Ten patients were infected by genotype 4. No patients were co-infected with HIV or HBV. Six patients (23.1% of patients) had significant fibrosis, of which five (19.2% of patients) were in the stage of cirrhosis. Twelve patients (46.2%) started treatment. Eleven were treatment-naïve and 1 did not respond to ribavirin-pegylated interferon-based therapy after 48 weeks. Ten cases of antiviral therapy were based on DAA and ribavirin-pegylated interferon in 2 patients. For the patients treated with peginterferon and ribavirin, a rapid virologic response was observed at 12 weeks in one patient, and the other patient was lost to follow-up. Among DAA-treated patients, 7 had sustained virologic responses at 12 weeks, 2 persisted, and 1 was lost to follow-up. Moderate thrombocytopenia and weight loss were observed in one patient receiving peginterferon and ribavirin. In our study, no patient died on treatment and no patients developed de novo HCC during or after DAA therapy. Conclusion: Viral hepatitis C is rare in Senegal. Despite the progress made in the therapeutic management of viral hepatitis C, it remains a challenge in Senegal. Indeed, DAAs are expensive and are not marketed, which makes them inaccessible to most patients.

关 键 词：Hepatitis C EPIDEMIOLOGY Diagnosis Treatment Senegal 

分 类 号：R51[医药卫生—内科学]