Clinical, Biological, Immunological and Therapeutic Profile of Patients Co-Infected with HIV-HBV and/or HCV in Kinshasa, in the Democratic Republic of the Congo: Multicenter Cross-Sectional Study  

作　　者：Jean-Paul Mayimona Kimpiatu Aliocha Natuhoyila Nkodila Antoine Wola Yaba Tshimpi Charles Nlombi Mbendi Thérèse Ndarabu Jean Jacques Matimbo Youyou Paka Patrick de Jésus Ngoma Blaise Batumona Trésor Monsere Pitchou Kengibe Jean Robert Rissassi Makulo Mireille Nganga Hippolyte Nani-Tuma Situakibanza Benjamin Longo Mbenza Jean-Paul Mayimona Kimpiatu;Aliocha Natuhoyila Nkodila;Antoine Wola Yaba Tshimpi;Charles Nlombi Mbendi;Thérèse Ndarabu;Jean Jacques Matimbo;Youyou Paka;Patrick de Jésus Ngoma;Blaise Batumona;Trésor Monsere;Pitchou Kengibe;Jean Robert Rissassi Makulo;Mireille Nganga;Hippolyte Nani-Tuma Situakibanza;Benjamin Longo Mbenza(Garstroenterology Department, University of Kinshasa, Kinshasa, Democratic Republic of the Congo;Departement of Family Medicine and Primary Health Care, Protestant University in Congo, Kinshasa, Democratic Republic of the Congo;Unit of Gastroenterology, Clinic Marie Yvette, Kinshasa, Democratic Republic of the Congo;Department of Nephrology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo;Department of Clinical Biology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo;Department of Infectious Diseases, University of Kinshasa, Kinshasa, Democratic Republic of the Congo;Department of Cardiology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo)

机构地区：[1]Garstroenterology Department, University of Kinshasa, Kinshasa, Democratic Republic of the Congo [2]Departement of Family Medicine and Primary Health Care, Protestant University in Congo, Kinshasa, Democratic Republic of the Congo [3]Unit of Gastroenterology, Clinic Marie Yvette, Kinshasa, Democratic Republic of the Congo [4]Department of Nephrology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo [5]Department of Clinical Biology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo [6]Department of Infectious Diseases, University of Kinshasa, Kinshasa, Democratic Republic of the Congo [7]Department of Cardiology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo

出　　处：《Open Journal of Gastroenterology》2022年第4期107-118,共12页肠胃病学期刊（英文）

摘　　要：Background and Objective: HIV infection is often associated with HBV and HCV infection, together leading to high morbidity and mortality in developing countries. The objective of this study is to describe the clinical, biological, immunological and therapeutic profile of patients co-infected with HIV-HBV and/or HCV. Methods: A cross-sectional and descriptive study including 180 people living with HIV (PLWHIV) in the city of Kinshasa province was conducted. Socio-demographic, clinical, biological and serological characteristics were analyzed. Results: The frequency of HIV-HBV/HCV co-infection was 23.9%. The distribution of age and sex of patients did not differ significantly according to co-infection status. The notion of pedicure and manicure was significantly more observed in patients free from viral hepatitis (51.1% versus 32.6%, p = 0.034). The median duration of knowledge of the HIV status which was longer in the co-infected (4 years versus 2 years, p = 0.022). A lower median level of GPT was observed in co-infected compared to other patients (14 IU/L versus 20 IU/L, p = 0.041). Serum albumin (3.1 g/L versus 3.3 g/L, p = 0.034) and prothrombin (58.3% versus 65.6%, p = 0.045) were lower in HIV co-infected-VHB and/or VHC. The median INR was higher in co-infected than in other patients (1.6 versus 1.4;p = 0.009). Patients without therapy Antiretroviral (TARV) medication were more numerous in co-infected (20.9% versus 8.0%, p = 0.025). Conclusions: The profile of PLWHIV was dominated by the presence of pedicures and manicures with high transaminases and without anti-viral treatment.Background and Objective: HIV infection is often associated with HBV and HCV infection, together leading to high morbidity and mortality in developing countries. The objective of this study is to describe the clinical, biological, immunological and therapeutic profile of patients co-infected with HIV-HBV and/or HCV. Methods: A cross-sectional and descriptive study including 180 people living with HIV (PLWHIV) in the city of Kinshasa province was conducted. Socio-demographic, clinical, biological and serological characteristics were analyzed. Results: The frequency of HIV-HBV/HCV co-infection was 23.9%. The distribution of age and sex of patients did not differ significantly according to co-infection status. The notion of pedicure and manicure was significantly more observed in patients free from viral hepatitis (51.1% versus 32.6%, p = 0.034). The median duration of knowledge of the HIV status which was longer in the co-infected (4 years versus 2 years, p = 0.022). A lower median level of GPT was observed in co-infected compared to other patients (14 IU/L versus 20 IU/L, p = 0.041). Serum albumin (3.1 g/L versus 3.3 g/L, p = 0.034) and prothrombin (58.3% versus 65.6%, p = 0.045) were lower in HIV co-infected-VHB and/or VHC. The median INR was higher in co-infected than in other patients (1.6 versus 1.4;p = 0.009). Patients without therapy Antiretroviral (TARV) medication were more numerous in co-infected (20.9% versus 8.0%, p = 0.025). Conclusions: The profile of PLWHIV was dominated by the presence of pedicures and manicures with high transaminases and without anti-viral treatment.

关 键 词：HIV-HCV-HBV Co-Infection Clinical Profile Biology TARVs KINSHASA 

分 类 号：R51[医药卫生—内科学]