Seroprevalence of Human Immunodeficiency Virus and Hepatitis B in Blood Donors at the N’Zérékoré Regional Blood Transfusion Centre in Guinea  

作　　者：Alimou Camara Ernest Thea Ives Nyankoye Haba Yamoussa Youla Ibrahima Sory Diallo Mariama Sadio Diallo Djiba Kaba Jacob Camara Moussa Condé Barré Soropogui Kaba Kourouma Thierno Mamadou Tounkara Babacar Mbengue Abdoulaye Touré Sanaba Boumbaly Alimou Camara;Ernest Thea;Ives Nyankoye Haba;Yamoussa Youla;Ibrahima Sory Diallo;Mariama Sadio Diallo;Djiba Kaba;Jacob Camara;Moussa Condé;Barré Soropogui;Kaba Kourouma;Thierno Mamadou Tounkara;Babacar Mbengue;Abdoulaye Touré;Sanaba Boumbaly(Virology Research Centre, Guinea Viral Haemorrhagic Fevers Laboratory, Conakry, Guinea;Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University, Conakry, Guinea;National Blood Transfusion Centre, Ministry of Health and Public Hygiene, Conakry, Guinea;Institute of Health and Childhood, Donka National Hospital, Conakry, Guinea;African Centre of Excellence for the Prevention and Control of Communicable Diseases, Conakry, Guinea;Department of Dermatology and Venereology, Donka University Hospital, Conakry, Guine;Immunology Laboratory, Cheikh Anta Diop University, Dakar, Senegal;Centre for Research and Training in Infectious Diseases of Guinea, Conakry, Guinea)

机构地区：[1]Virology Research Centre, Guinea Viral Haemorrhagic Fevers Laboratory, Conakry, Guinea [2]Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University, Conakry, Guinea [3]National Blood Transfusion Centre, Ministry of Health and Public Hygiene, Conakry, Guinea [4]Institute of Health and Childhood, Donka National Hospital, Conakry, Guinea [5]African Centre of Excellence for the Prevention and Control of Communicable Diseases, Conakry, Guinea [6]Department of Dermatology and Venereology, Donka University Hospital, Conakry, Guine [7]Immunology Laboratory, Cheikh Anta Diop University, Dakar, Senegal [8]Centre for Research and Training in Infectious Diseases of Guinea, Conakry, Guinea

出　　处：《Open Journal of Immunology》2024年第2期33-45,共13页免疫学期刊（英文）

摘　　要：Blood transfusion saves lives and reduces morbidity and mortality for a large number of diseases and clinical conditions, but it is not without danger. The aim of this study was to determine the seroprevalence of HIV and hepatitis B in blood donors received at the regional Blood Transfusion Centre of N’Zérékoré (Guinea). This was a 5-year retrospective analytical study. We included records of blood donors aged 18 to 60 years admitted to the N’Zérékoré Regional Blood Transfusion Centre for blood donation from January 2016 to December 2020. We performed a descriptive analysis followed by Chi-2 or Fish-er-exact tests and the Student or Wilcoxon test, followed by multivariate logistic regression. In this study, donor age ranged from 18 - 60 years, with a pre-dominance of donors aged 25 - 34 (44.2%). Male donors were the most represented in our study (79.0% versus 21.0% female). More than half of the donors were blood group O (55.6%). We observed a seroprevalence of 3.6% for HIV, 13.4% for HBsAg and 0.2% for co-infection. In our series, age 25 - 34 (OR = 1.89 and P = 0.001) and 35 - 44 for HIV (OR = 2.01 and P = 0.001), HBsAgserostatus (OR = 3.04 and P = 0.001) and blood donation history (OR of 3.04 and P = 0.001) were factors associated with HIV positivity (P < 0.05). In our study, HIV serostatus (OR = 3.04 and P = 0.001) and blood donation history (OR = 0.01 and P = 0.001) were factors associated with HBsAgseropositivity. We reported a high prevalence of HIV and HBsAg. Sex, serological status and blood donation history were associated factors.Blood transfusion saves lives and reduces morbidity and mortality for a large number of diseases and clinical conditions, but it is not without danger. The aim of this study was to determine the seroprevalence of HIV and hepatitis B in blood donors received at the regional Blood Transfusion Centre of N’Zérékoré (Guinea). This was a 5-year retrospective analytical study. We included records of blood donors aged 18 to 60 years admitted to the N’Zérékoré Regional Blood Transfusion Centre for blood donation from January 2016 to December 2020. We performed a descriptive analysis followed by Chi-2 or Fish-er-exact tests and the Student or Wilcoxon test, followed by multivariate logistic regression. In this study, donor age ranged from 18 - 60 years, with a pre-dominance of donors aged 25 - 34 (44.2%). Male donors were the most represented in our study (79.0% versus 21.0% female). More than half of the donors were blood group O (55.6%). We observed a seroprevalence of 3.6% for HIV, 13.4% for HBsAg and 0.2% for co-infection. In our series, age 25 - 34 (OR = 1.89 and P = 0.001) and 35 - 44 for HIV (OR = 2.01 and P = 0.001), HBsAgserostatus (OR = 3.04 and P = 0.001) and blood donation history (OR of 3.04 and P = 0.001) were factors associated with HIV positivity (P < 0.05). In our study, HIV serostatus (OR = 3.04 and P = 0.001) and blood donation history (OR = 0.01 and P = 0.001) were factors associated with HBsAgseropositivity. We reported a high prevalence of HIV and HBsAg. Sex, serological status and blood donation history were associated factors.

关 键 词：SEROPREVALENCE HIV Hepatitis B Blood Donors N’Zérékoré GUINEA 

分 类 号：R51[医药卫生—内科学]