机构地区：[1]Hospital Escuela Antonio Lenin Fonseca, Managua, Nicaragua [2]Seniors Clinic, Managua, Nicaragua [3]Catalysis SL, Madrid, Spain
出 处：《Open Journal of Nephrology》2021年第1期78-92,共15页肾脏病（英文）
摘 要：<b><span>Background</span></b><b><span>: </span></b><span>In view of the high recurrence of kidney stones in patients, the search for less aggressive, preventive treatments has become increasingly essential. Renalof</span><sup><span style="vertical-align:super;"><span style="white-space:nowrap;">®</span></span></sup><span> offers a phytotherapy alternative. Due to its diuretic and kidney stone demineralisation properties, it has been widely used in this patient population, disintegrating and eliminating calcium oxalate and struvite kidney stones painlessly in the genitourinary system. </span><b><span>Methods</span></b><b><span>: </span></b><span>A Phase II, randomised, prospective, observational, single-blind study with two treatment arms was conducted in order to determine the efficacy of this alternative therapy: a total of 155 patients were enrolled, 120 were assigned to a Renalof</span><sup><span style="vertical-align:super;"><span style="white-space:nowrap;">®</span></span></sup><span> treatment group and 35 to the placebo group. All were over 18 years of age, of both genders, diagnosed with kidney stones of under 10 mm in diameter, present along the entire renal-ureteral-vesicular tract, diagnosed by ultrasound and renal CAT scan. Divided into two study arms, 120 were administered a dosage of a single 325 mg capsule of the Renalof</span><sup><span style="vertical-align:super;"><span style="white-space:nowrap;">®</span></span></sup><span> product half an hour before the two main meals for 3 months. The presence of kidney stones in any part of the renal-ureteral tract was assessed at monthly consultations using one of the above-mentioned diagnostic tools. </span><b><span>Results</span></b><b><span>: </span></b><span>Study results show a high rate of effectiveness with Renalof</span><sup><span style="vertical-align:super;"><span style="white-space:nowrap;">®</span></span></sup><span>, finding up to a 65% expulsion rate (78 patients) in the first 8 weeks of treatment, compared to 11.4% (4 pa<b><span>Background</span></b><b><span>: </span></b><span>In view of the high recurrence of kidney stones in patients, the search for less aggressive, preventive treatments has become increasingly essential. Renalof</span><sup><span style="vertical-align:super;"><span style="white-space:nowrap;">®</span></span></sup><span> offers a phytotherapy alternative. Due to its diuretic and kidney stone demineralisation properties, it has been widely used in this patient population, disintegrating and eliminating calcium oxalate and struvite kidney stones painlessly in the genitourinary system. </span><b><span>Methods</span></b><b><span>: </span></b><span>A Phase II, randomised, prospective, observational, single-blind study with two treatment arms was conducted in order to determine the efficacy of this alternative therapy: a total of 155 patients were enrolled, 120 were assigned to a Renalof</span><sup><span style="vertical-align:super;"><span style="white-space:nowrap;">®</span></span></sup><span> treatment group and 35 to the placebo group. All were over 18 years of age, of both genders, diagnosed with kidney stones of under 10 mm in diameter, present along the entire renal-ureteral-vesicular tract, diagnosed by ultrasound and renal CAT scan. Divided into two study arms, 120 were administered a dosage of a single 325 mg capsule of the Renalof</span><sup><span style="vertical-align:super;"><span style="white-space:nowrap;">®</span></span></sup><span> product half an hour before the two main meals for 3 months. The presence of kidney stones in any part of the renal-ureteral tract was assessed at monthly consultations using one of the above-mentioned diagnostic tools. </span><b><span>Results</span></b><b><span>: </span></b><span>Study results show a high rate of effectiveness with Renalof</span><sup><span style="vertical-align:super;"><span style="white-space:nowrap;">®</span></span></sup><span>, finding up to a 65% expulsion rate (78 patients) in the first 8 weeks of treatment, compared to 11.4% (4 pa
关 键 词：UROLITHIASIS Renal Colic Kidney Stones Agropyron Repens Calcium Oxalate
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