Focal Segmantal Glomerulosclerosis: Epidemiological, Clinico-Biological, Pathological, Etiological, Therapeutic and Evolutionary Profiles in Dakar  

作　　者：Pierre Eric Gandzali Ngabe Djibrilla Bonkano Baoua Aida Habi Yabana Lengani Hamadoun Yattara Adama Kama Yatte Richard Loumingou Lemrabott Tall Elhadji Fary Ka Abdou Niang Boucar Diouf Pierre Eric Gandzali Ngabe;Djibrilla Bonkano Baoua;Aida Habi Yabana Lengani;Hamadoun Yattara;Adama Kama Yatte;Richard Loumingou;Lemrabott Tall;Elhadji Fary Ka;Abdou Niang;Boucar Diouf(Department of Nephrology and Hemodialysis, General Teaching Hospital, Brazzaville, Republic of the Congo;Department of Nephrology and Hemodialysis, Amirou Boubacar Diallo National Hospital, Niamey, Niger;Department of Nephrology and Hemodialysis, Yalgado Ouedraogo, Ouagadougou, Burkina Faso;Department of Nephrology and Hemodialysis, General Teaching Hospital POINT G, Bamako, Mali;Department of Nephrology, Dialysis and Kydney Transplantation, ARISTIDE LE DANTEC Hospital, Dakar, Senegal)

机构地区：[1]Department of Nephrology and Hemodialysis, General Teaching Hospital, Brazzaville, Republic of the Congo [2]Department of Nephrology and Hemodialysis, Amirou Boubacar Diallo National Hospital, Niamey, Niger [3]Department of Nephrology and Hemodialysis, Yalgado Ouedraogo, Ouagadougou, Burkina Faso [4]Department of Nephrology and Hemodialysis, General Teaching Hospital POINT G, Bamako, Mali [5]Department of Nephrology, Dialysis and Kydney Transplantation, ARISTIDE LE DANTEC Hospital, Dakar, Senegal

出　　处：《Open Journal of Nephrology》2023年第2期174-195,共21页肾脏病（英文）

摘　　要：Introduction: Focal Segmental Glomerulosclerosis (FSGS) corresponds to a clinicopathological syndrome, manifested by generally abundant proteinuria associated with hyaline deposits on part of certain glomeruli and sparing other glomeruli, with effacement of the pedicels. The general objective was to determine the prevalence of FSGS, and to give its profiles;epidemiological, clinical, biological, pathological, etiological, therapeutic and evolutionary of FSGS. Materials and Methods: This is a retrospective analytical study over a period of six years extending from January 1, 2010 to December 31, 2015 patients aged 16 or over who were hospitalized or received consultations during the study period for primary or secondary segmental and focal hyalinosis. Patients whose records were incomplete or unusable were not included in the study. Results: We have 16.54% with 158 cases of FSGS out of 6945 patients received and/or hospitalized. Of the 955 kidney biopsies distributed, the incidences of HSF were;10.15%;14.04%;15%;17.64%;20.11%;19.58% respectively in 2010;2011;2012;2013;2014 and 2015, i.e. an annual increase of around 1.25%. Renal-type edemas were found in 93.3%, the first reason for hospitalization. And ninety-six people had impaired kidney function, or 61%. The average of 24-hour proteinuria was 6.4 ± 3.69 g/24 hours. The extremes were 0.37 and 18.50 g/24h. Patients had nephrotic proteinuria in 84.86%. Non-specific FSGS or NOS (Not Other Specificities) was found in 62 cases or 39.24%, collapsing FSGS in 48 cases or 30.40%. FSGS with found causes was associated with fibrosis in 5/35 cases. Collapsing FSGSs followed by NOS FSGSs were the most corticosteroid-resistant. The evolution of the FSGS reveals that every 8 months the proteinuria decreases by half. Conclusion: Segmental and focal hyalinosis requires histological confirmation and the epidemiological, clinico-biological, etiological, therapeutic and evolutionary profiles depend on the histological (pathological) type. Other works on the risk factors for occurrIntroduction: Focal Segmental Glomerulosclerosis (FSGS) corresponds to a clinicopathological syndrome, manifested by generally abundant proteinuria associated with hyaline deposits on part of certain glomeruli and sparing other glomeruli, with effacement of the pedicels. The general objective was to determine the prevalence of FSGS, and to give its profiles;epidemiological, clinical, biological, pathological, etiological, therapeutic and evolutionary of FSGS. Materials and Methods: This is a retrospective analytical study over a period of six years extending from January 1, 2010 to December 31, 2015 patients aged 16 or over who were hospitalized or received consultations during the study period for primary or secondary segmental and focal hyalinosis. Patients whose records were incomplete or unusable were not included in the study. Results: We have 16.54% with 158 cases of FSGS out of 6945 patients received and/or hospitalized. Of the 955 kidney biopsies distributed, the incidences of HSF were;10.15%;14.04%;15%;17.64%;20.11%;19.58% respectively in 2010;2011;2012;2013;2014 and 2015, i.e. an annual increase of around 1.25%. Renal-type edemas were found in 93.3%, the first reason for hospitalization. And ninety-six people had impaired kidney function, or 61%. The average of 24-hour proteinuria was 6.4 ± 3.69 g/24 hours. The extremes were 0.37 and 18.50 g/24h. Patients had nephrotic proteinuria in 84.86%. Non-specific FSGS or NOS (Not Other Specificities) was found in 62 cases or 39.24%, collapsing FSGS in 48 cases or 30.40%. FSGS with found causes was associated with fibrosis in 5/35 cases. Collapsing FSGSs followed by NOS FSGSs were the most corticosteroid-resistant. The evolution of the FSGS reveals that every 8 months the proteinuria decreases by half. Conclusion: Segmental and focal hyalinosis requires histological confirmation and the epidemiological, clinico-biological, etiological, therapeutic and evolutionary profiles depend on the histological (pathological) type. Other works on the risk factors for occurr

关 键 词：PROTEINURIA CORTICOTHERAPY Focal Segmantal Glomerulosclerosis Senegal 

分 类 号：R69[医药卫生—泌尿科学]