Clinical Presentation and Treatment Outcomes of Pregnancy-Related Acute Kidney Injury among Pregnant Women Admitted at the Benjamin Mkapa Hospital in Tanzania  

作　　者：Kessy Shija Hindu Ibrahim Sylvia Jumbe Bushi Lugoba Stephen Mathew Kibusi Alphonce Chandika Kessy Shija;Hindu Ibrahim;Sylvia Jumbe;Bushi Lugoba;Stephen Mathew Kibusi;Alphonce Chandika(Department of Nephrology and Urology, Benjamin Mkapa Hospital, Dodoma, Tanzania;Clinical Research and Innovation, Benjamin Mkapa Hospital, Dodoma, Tanzania;Outreach Services and Clinical Coordination, Benjamin Mkapa Hospital, Dodoma, Tanzania;Clinical Audit and Quality Assurance, Benjamin Mkapa Hospital, Dodoma, Tanzania;School of Nursing and Public Health, University of Dodoma, Dodoma, Tanzania;Executive Director, Benjamin Mkapa Hospital, Dodoma, Tanzania)

机构地区：[1]Department of Nephrology and Urology, Benjamin Mkapa Hospital, Dodoma, Tanzania [2]Clinical Research and Innovation, Benjamin Mkapa Hospital, Dodoma, Tanzania [3]Outreach Services and Clinical Coordination, Benjamin Mkapa Hospital, Dodoma, Tanzania [4]Clinical Audit and Quality Assurance, Benjamin Mkapa Hospital, Dodoma, Tanzania [5]School of Nursing and Public Health, University of Dodoma, Dodoma, Tanzania [6]Executive Director, Benjamin Mkapa Hospital, Dodoma, Tanzania

出　　处：《Open Journal of Nephrology》2024年第2期157-175,共19页肾脏病（英文）

摘　　要：Background: Globally, PRAKI is among the leading causes of death in pregnant women. The prevalence, causes and outcome of this condition vary among countries due to differences in environmental, socioeconomic, and health delivery systems. The common causes that have been reported in several studies are PIH, Haemorrhages and Sepsis while the outcomes may be either complete renal recovery, progression to CKD and hence dialysis dependency or death. This study aimed at determining clinical presentation and treatment outcomes of Pregnancy-Related Acute Kidney Injury in Pregnant women admitted at the Benjamin Mkapa Hospital, Dodoma, Tanzania. Results: Out of 4007 pregnant women who were admitted to the maternity ward 51 pregnant women were found to have PRAKI. Of those with PRAKI, 74.5% were between 21 to 25 years. The leading causes of PRAKI were PPH 12 (23.53%), Eclampsia 12 (23.53%), and pre-eclampsia 12 (23.5%). Hemodialysis therapy was provided to 22 (43.1%) patients, 15 (29.4%) individuals recovered spontaneously with medical management and 14 (27.5%) missed haemodialysis therapy due to various reasons. The mortality due to PRAKI was 17 (33.3%). Conclusion and Recommendation: Pre-eclampsia/eclampsia and post-partum haemorrhage were found to be the main causes of PRAKI. The mortality related to PRAKI is high and Hemodialysis therapy is vital help to prevent deaths for pregnant women with PRAKI. Pregnant women who develop acute kidney injury should be followed closely and a nephrologist should be consulted early. Early referral should be done by the lower level facilities for all at-risk pregnant women to a specialized multidisciplinary health facility.Background: Globally, PRAKI is among the leading causes of death in pregnant women. The prevalence, causes and outcome of this condition vary among countries due to differences in environmental, socioeconomic, and health delivery systems. The common causes that have been reported in several studies are PIH, Haemorrhages and Sepsis while the outcomes may be either complete renal recovery, progression to CKD and hence dialysis dependency or death. This study aimed at determining clinical presentation and treatment outcomes of Pregnancy-Related Acute Kidney Injury in Pregnant women admitted at the Benjamin Mkapa Hospital, Dodoma, Tanzania. Results: Out of 4007 pregnant women who were admitted to the maternity ward 51 pregnant women were found to have PRAKI. Of those with PRAKI, 74.5% were between 21 to 25 years. The leading causes of PRAKI were PPH 12 (23.53%), Eclampsia 12 (23.53%), and pre-eclampsia 12 (23.5%). Hemodialysis therapy was provided to 22 (43.1%) patients, 15 (29.4%) individuals recovered spontaneously with medical management and 14 (27.5%) missed haemodialysis therapy due to various reasons. The mortality due to PRAKI was 17 (33.3%). Conclusion and Recommendation: Pre-eclampsia/eclampsia and post-partum haemorrhage were found to be the main causes of PRAKI. The mortality related to PRAKI is high and Hemodialysis therapy is vital help to prevent deaths for pregnant women with PRAKI. Pregnant women who develop acute kidney injury should be followed closely and a nephrologist should be consulted early. Early referral should be done by the lower level facilities for all at-risk pregnant women to a specialized multidisciplinary health facility.

关 键 词：Clinical Presentation Treatment Outcomes Pregnancy-Related Acute Kidney Injury 

分 类 号：R69[医药卫生—泌尿科学]