Predictive Factors of Renal Damage during Sickle Cell Disease at the Hematology-Oncology Department of Donka University Hospital  

作　　者：Moussa Traoré Ansoumane Sayon Kanté Marthe Sidibé Mamady Diakité Mohammed Lamine Tégui Camara Foussény Diakité Mamadou Saliou Baldé Ibrahima Chérif Mustapha Komrabai-Kanu Mohammed Lamine Kaba Moussa Traoré;Ansoumane Sayon Kanté;Marthe Sidibé;Mamady Diakité;Mohammed Lamine Tégui Camara;Foussény Diakité;Mamadou Saliou Baldé;Ibrahima Chérif;Mustapha Komrabai-Kanu;Mohammed Lamine Kaba(Nephrology-Hemodialysis Department of Donka University Hospital, Conakry, Guinea;Hematology-Oncology Department of Donka University Hospital, Conakry, Guinea;Hematology-Oncology Department of Ignace Deen University Hospital, Conakry, Guinea;Medical Care Clinic, Freetown, Sierra-Leone)

机构地区：[1]Nephrology-Hemodialysis Department of Donka University Hospital, Conakry, Guinea [2]Hematology-Oncology Department of Donka University Hospital, Conakry, Guinea [3]Hematology-Oncology Department of Ignace Deen University Hospital, Conakry, Guinea [4]Medical Care Clinic, Freetown, Sierra-Leone

出　　处：《Open Journal of Nephrology》2024年第3期302-312,共11页肾脏病（英文）

摘　　要：Introduction: Sickle cell disease, which is the most common hereditary hemoglobinopathy in the world, attacks all body systems, particularly the kidneys. The view of this study was to investigate the predictive factors of kidney damage during sickle cell disease. Materials and methods: It was a retrospective, descriptive and analytical study on files of sickle cell patients hospitalized in the Hematology-Oncology Department of Donka University Hospital during a period from January 1, 2016 to December 31, 2019. Records of sickle cell patients with one or more renal abnormalities were retained. Sickle cell patients without kidney damage were also selected for a comparative study. Only patients without sickle cell disease were excluded. Results: Seventy-five (75) medical records were collected during the study period. From these cases, thirteen (13) records with kidney disease were observed, a frequency of 17%. The mean age of patients was 24.2 years for extremes of 10 and 65 years. The sex ratio was 1.6 in favor of men. The SSFA2 form was the most represented with 92%. 24-hour proteinuria was measured in 13 patients between whom 6 patients (46.2%) had a proteinuria level ≤ 1 g. Eight (8) patients (61.5%) were in stage 1 of chronic kidney disease. The most common type of renal involvement was tubulo-interstitial nephropathy with 8 patients (61.5%). Bivariate analysis showed that elevated serum creatinine (P 2 form of the sickness (P Conclusion: After the observation of an increased serum creatinine and urea, a predominance observation of the SSFA2 form, it should be possible to target patients for whom screening for kidney damage should henceforth be systematic.Introduction: Sickle cell disease, which is the most common hereditary hemoglobinopathy in the world, attacks all body systems, particularly the kidneys. The view of this study was to investigate the predictive factors of kidney damage during sickle cell disease. Materials and methods: It was a retrospective, descriptive and analytical study on files of sickle cell patients hospitalized in the Hematology-Oncology Department of Donka University Hospital during a period from January 1, 2016 to December 31, 2019. Records of sickle cell patients with one or more renal abnormalities were retained. Sickle cell patients without kidney damage were also selected for a comparative study. Only patients without sickle cell disease were excluded. Results: Seventy-five (75) medical records were collected during the study period. From these cases, thirteen (13) records with kidney disease were observed, a frequency of 17%. The mean age of patients was 24.2 years for extremes of 10 and 65 years. The sex ratio was 1.6 in favor of men. The SSFA2 form was the most represented with 92%. 24-hour proteinuria was measured in 13 patients between whom 6 patients (46.2%) had a proteinuria level ≤ 1 g. Eight (8) patients (61.5%) were in stage 1 of chronic kidney disease. The most common type of renal involvement was tubulo-interstitial nephropathy with 8 patients (61.5%). Bivariate analysis showed that elevated serum creatinine (P 2 form of the sickness (P Conclusion: After the observation of an increased serum creatinine and urea, a predominance observation of the SSFA2 form, it should be possible to target patients for whom screening for kidney damage should henceforth be systematic.

关 键 词：Kidney Damage Predictive Factors Sickle Cell Disease Donka 

分 类 号：R69[医药卫生—泌尿科学]