Is There Any Role for Calcium Ionophore in ICSI Cycles for Cases of Non Obstructive Azoospermia?  

作　　者：Mohamed Elmahdy Yasser Oreif Soad Musleh Emadeldin Khalifa Mohamed Elmahdy;Yasser Oreif;Soad Musleh;Emadeldin Khalifa(Obstetrics and Gynecology, Alexandria University, Alexandria, Egypt)

机构地区：[1]Obstetrics and Gynecology, Alexandria University, Alexandria, Egypt

出　　处：《Open Journal of Obstetrics and Gynecology》2021年第8期1037-1049,共13页妇产科期刊（英文）

摘　　要：<strong>Objectives:</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> Evaluate the effect of artificial oocyte activation (AOA) using calcium ionophore (A23187) on the rate of fertilization and cleavage of embryos in surgically retrieved sperm of patients with non-obstructive azoospermia undergoing intracytoplasmic sperm injection (ICSI).</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Study design: </span></b></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">This study was conducted on 60 infertile couples undergoing ICSI cycles as a randomized controlled parallel group’s experimental study in a private IVF center in Egypt from January 2018 to July 2019. ICSI cycles were divided into two g</span><span style="font-family:Verdana;">roups: Group A: includes 30 ICSI patients with surgically retrieved sperms of non-obstructive azoospermia treated with calcium ionophore (A23187). Group C/Control: includes 30 ICSI patients with surgically retrieved sperms of non-obstructive azoospermia non-treated with calcium ionophore (A23187)</span><span style="font-family:Verdana;">. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">There was no statistical difference between both groups regarding the fertilization rate (</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.853). There was no statistical difference between them regarding implantation rate (</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.237). The percentage of Class A embryos in the ca ionophore group was 81.7%, while it was 82.8% in the control group. There was insignificant difference between them (</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Ve<strong>Objectives:</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> Evaluate the effect of artificial oocyte activation (AOA) using calcium ionophore (A23187) on the rate of fertilization and cleavage of embryos in surgically retrieved sperm of patients with non-obstructive azoospermia undergoing intracytoplasmic sperm injection (ICSI).</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Study design: </span></b></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">This study was conducted on 60 infertile couples undergoing ICSI cycles as a randomized controlled parallel group’s experimental study in a private IVF center in Egypt from January 2018 to July 2019. ICSI cycles were divided into two g</span><span style="font-family:Verdana;">roups: Group A: includes 30 ICSI patients with surgically retrieved sperms of non-obstructive azoospermia treated with calcium ionophore (A23187). Group C/Control: includes 30 ICSI patients with surgically retrieved sperms of non-obstructive azoospermia non-treated with calcium ionophore (A23187)</span><span style="font-family:Verdana;">. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">There was no statistical difference between both groups regarding the fertilization rate (</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.853). There was no statistical difference between them regarding implantation rate (</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.237). The percentage of Class A embryos in the ca ionophore group was 81.7%, while it was 82.8% in the control group. There was insignificant difference between them (</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Ve

关 键 词：Fertilization Failure ICSI Azosperemia Ca Ionophore 

分 类 号：R69[医药卫生—泌尿科学]