Comparative Study between the Use of Regular Folic Acid Supplement versus the Use of L-Methyl Folate in Patients with Methyl Tetrahydrofolate Reductase (MTHFR) Gene Mutation with Recurrent Pregnancy Loss  

作　　者：Ahmed Essmat Ahmed Essmat(Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Alexandria, Egypt)

机构地区：[1]Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Alexandria, Egypt

出　　处：《Open Journal of Obstetrics and Gynecology》2021年第9期1104-1111,共8页妇产科期刊（英文）

摘　　要：<strong>Background:</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> Methylfolate is the active metabolite of folate that is importa</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">nt for DNA repair, synthetized under the effect of MTHFR (methyl-tetrahydro-folatereductase) enzyme. Patients with MTHFR gene mutation have low levels of biologically active methyfolate. Those patients have high homocysteine levels causing vasculopathy and inadequate feto-maternal circulation. </span><b><span style="font-family:Verdana;">Aim of the Work:</span></b><span style="font-family:Verdana;"> To predict the potential benefit of use of methylfolate instead of use of the regular folic acid in patients with MTHFR gene mutation with history of RPL</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">(recurrent pregnancy loss). </span><b><span style="font-family:Verdana;">Subjects and Methods:</span></b><span style="font-family:Verdana;"> Study was performed on 100 women. All women had experienced at least two consecutive miscarriages first trimester abortion. All patients were positive of </span><span style="font-family:Verdana;">having MTHFR gene mutation. Patients were divided into two groups in terms of 1st trimester drug intake. The 1st group recieved a regular folic acid supplement in a dose of 5</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">mg per day starting from the day of positive preg</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">nancy test till the end of the first trimester.</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style<strong>Background:</strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> Methylfolate is the active metabolite of folate that is importa</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">nt for DNA repair, synthetized under the effect of MTHFR (methyl-tetrahydro-folatereductase) enzyme. Patients with MTHFR gene mutation have low levels of biologically active methyfolate. Those patients have high homocysteine levels causing vasculopathy and inadequate feto-maternal circulation. </span><b><span style="font-family:Verdana;">Aim of the Work:</span></b><span style="font-family:Verdana;"> To predict the potential benefit of use of methylfolate instead of use of the regular folic acid in patients with MTHFR gene mutation with history of RPL</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">(recurrent pregnancy loss). </span><b><span style="font-family:Verdana;">Subjects and Methods:</span></b><span style="font-family:Verdana;"> Study was performed on 100 women. All women had experienced at least two consecutive miscarriages first trimester abortion. All patients were positive of </span><span style="font-family:Verdana;">having MTHFR gene mutation. Patients were divided into two groups in terms of 1st trimester drug intake. The 1st group recieved a regular folic acid supplement in a dose of 5</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">mg per day starting from the day of positive preg</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">nancy test till the end of the first trimester.</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style

关 键 词：MTHFR Recurrent Pregnancy Loss Folic Acid L-Methylfolate 

分 类 号：R71[医药卫生—妇产科学]