Benefit of Iron Supplementation with Ferric Sodium EDTA (NaFe ³⁺-EDTA) in the Treatment of Anemia during Pregnancy in Democratic Republic of Congo (FERARI Study)  

作　　者：Muela Andy Mbangama Difunda Victor Muela Mwimba Roger Mbungu Moyenne Jean Pierre Elongi Ambis Joëlle Lumaya Ndombasi Nelda Lemba Umba Adrien Tandu Otem Christian Ndesanzim Nkashama Bienvenu Kazadi Litambelo Serge Etana Muela Andy Mbangama;Difunda Victor Muela;Mwimba Roger Mbungu;Moyenne Jean Pierre Elongi;Ambis Joëlle Lumaya;Ndombasi Nelda Lemba;Umba Adrien Tandu;Otem Christian Ndesanzim;Nkashama Bienvenu Kazadi;Litambelo Serge Etana(Department of Gynecology and Obstetrics, University Clinics of Kinshasa, Kinshasa, DR Congo;Congolese Society of Gynecology and Obstetrics, Kinshasa, DR Congo;Department of Gynecology and Obstetrics, Kinshasa Provincial General Reference Hospital, Kinshasa, DR Congo)

机构地区：[1]Department of Gynecology and Obstetrics, University Clinics of Kinshasa, Kinshasa, DR Congo [2]Congolese Society of Gynecology and Obstetrics, Kinshasa, DR Congo [3]Department of Gynecology and Obstetrics, Kinshasa Provincial General Reference Hospital, Kinshasa, DR Congo

出　　处：《Open Journal of Obstetrics and Gynecology》2021年第10期1411-1424,共14页妇产科期刊（英文）

摘　　要：<strong>Background:</strong><span style="font-family:;" "=""><span> Oral iron supplements, usually in the form of ferrous salts, are associated with gastric side effects, poor compliance and failure of anemia treatment. To make iron more bioavailable, reduce the gastric side effects and increase the patient compliance, newer iron form, Ferric Sodium EDTA, has become available on the market. </span><b><span>Objective:</span></b><span> To assess the change in hemog</span><span>lobin level after iron supplementation with Ferric Sodium EDTA during </span><span>pregnancy. </span><b><span>Materials and Methods:</span></b><span> This is a longitudinal study concerning 337 </span><span>women attending antenatal care in maternity hospitals in the Democratic</span> <span>Republic of Congo from May to December 2020. The study included soci</span><span>odemographic and anthropometric variables along with type of feed, hemoglobin </span><span>level at recruitment and after three weeks of taking iron supplement with</span><span> Ferric Sodium EDTA (Hemoforce Plus Zinc</span></span>^{<span><span>^{</span><span>&reg;</span><span>}</span></span>}<span style="font-family:;" "=""><span> syrup). For statistical analysis, we used t-test or ANOVA and chi-square test, the significance being stated at p < 0.05. </span><b><span>Results:</span></b><span> The frequency of pregnancy anemia was 51.4%. The mean </span><span>hemoglobin value of the overall study group was 8.7 ± 0.5 g/dL. The mean</span><span> maternal age and weight were 28.9 ± 6.2 years and 65.3 ± 11.7 kg, respectively. Most pregnant women (83.1%) had a diet consisting of food of plant and animal origin in equal proportions. Mean of Body Mass Index (BMI) was 24.6 ± 4.6 Kg/m</span>^{<span>2</span>}<span> and 44.3% were overweight and obese. The co-morbidities associated were malaria and intestinal parasitosis found in 45% and 5.9% of cases, </span><span>respectively. After iron treatment with Ferric Sodium EDTA, the average</span><span> hemoglobin l<strong>Background:</strong><span style="font-family:;" "=""><span> Oral iron supplements, usually in the form of ferrous salts, are associated with gastric side effects, poor compliance and failure of anemia treatment. To make iron more bioavailable, reduce the gastric side effects and increase the patient compliance, newer iron form, Ferric Sodium EDTA, has become available on the market. </span><b><span>Objective:</span></b><span> To assess the change in hemog</span><span>lobin level after iron supplementation with Ferric Sodium EDTA during </span><span>pregnancy. </span><b><span>Materials and Methods:</span></b><span> This is a longitudinal study concerning 337 </span><span>women attending antenatal care in maternity hospitals in the Democratic</span> <span>Republic of Congo from May to December 2020. The study included soci</span><span>odemographic and anthropometric variables along with type of feed, hemoglobin </span><span>level at recruitment and after three weeks of taking iron supplement with</span><span> Ferric Sodium EDTA (Hemoforce Plus Zinc</span></span>^{<span><span>^{</span><span>&reg;</span><span>}</span></span>}<span style="font-family:;" "=""><span> syrup). For statistical analysis, we used t-test or ANOVA and chi-square test, the significance being stated at p < 0.05. </span><b><span>Results:</span></b><span> The frequency of pregnancy anemia was 51.4%. The mean </span><span>hemoglobin value of the overall study group was 8.7 ± 0.5 g/dL. The mean</span><span> maternal age and weight were 28.9 ± 6.2 years and 65.3 ± 11.7 kg, respectively. Most pregnant women (83.1%) had a diet consisting of food of plant and animal origin in equal proportions. Mean of Body Mass Index (BMI) was 24.6 ± 4.6 Kg/m</span>^{<span>2</span>}<span> and 44.3% were overweight and obese. The co-morbidities associated were malaria and intestinal parasitosis found in 45% and 5.9% of cases, </span><span>respectively. After iron treatment with Ferric Sodium EDTA, the average</span><span> hemoglobin l

关 键 词：Iron Supplementation Ferric Sodium EDTA NaFe³⁺-EDTA ANEMIA PREGNANCY 

分 类 号：O17[理学—数学]