Risk Factors for Preterm Delivery in Asymptomatic Singleton Pregnant Women with a Sonographic Short Cervix  

作　　者：Satoshi Yoneda Noriko Yoneda Shigeru Saito Satoshi Yoneda;Noriko Yoneda;Shigeru Saito(Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan)

机构地区：[1]Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan

出　　处：《Open Journal of Obstetrics and Gynecology》2021年第12期1711-1724,共14页妇产科期刊（英文）

摘　　要：<strong>Objectives:</strong> <span><span><span style="font-family:""><span style="font-family:Verdana;">Although an asymptomatic short cervix is a risk factor for spontaneous preterm birth (SPTB), the risk factors for SPTB among those with short cervix remain unknown. We herein investigated risk factors for preterm delivery (PTD) at <34 weeks of gestation in pregnant women with a short cervix. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> This was a retrospective study. Seventy-three asymptomatic pregnant women with a sonographic short cervix (excluding visible bulging fetal membranes) were selected, and the relationship between clinical or biochemical risk factors and preterm delivery (PTD) at <34 weeks was examined.</span><b><span style="font-family:Verdana;"> Results: </span></b><span style="font-family:Verdana;">Thirteen cases (17.8%) had PTD at <34 weeks. A univariate analysis showed that a history of SPTD, gestational weeks on admission, cervical length, cervical mucus interleukin (CM-IL)-8 and amniotic fluid interleukin (AF-IL)-8 in PTD at <34 weeks significantly differed from those in delivery at </span><span style="font-family:Verdana;">≥34 weeks (p < 0.05, respectively). A multiple logistic regression analysis i</span><span style="font-family:Verdana;">dentified CM-IL-8 ≥ 803.5 ng/mL [21.3 (3.0 - 260), </span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.002] and cervical length ≤15 mm [17.1 (1.9 - 517), </span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.008] as independent risk factors for PTD at <34 weeks.</span><b><span style="font-family:Verdana;"> Conclusions:</span></b><span style="font-family:Verdana;"> Evaluation for cervical inflammation may be necessary for appropriate treatment strategies in asymptomatic pregnant women with a short cervix. Cervical inflammation warrants further study.</span></span></span></span><strong>Objectives:</strong> <span><span><span style="font-family:""><span style="font-family:Verdana;">Although an asymptomatic short cervix is a risk factor for spontaneous preterm birth (SPTB), the risk factors for SPTB among those with short cervix remain unknown. We herein investigated risk factors for preterm delivery (PTD) at <34 weeks of gestation in pregnant women with a short cervix. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> This was a retrospective study. Seventy-three asymptomatic pregnant women with a sonographic short cervix (excluding visible bulging fetal membranes) were selected, and the relationship between clinical or biochemical risk factors and preterm delivery (PTD) at <34 weeks was examined.</span><b><span style="font-family:Verdana;"> Results: </span></b><span style="font-family:Verdana;">Thirteen cases (17.8%) had PTD at <34 weeks. A univariate analysis showed that a history of SPTD, gestational weeks on admission, cervical length, cervical mucus interleukin (CM-IL)-8 and amniotic fluid interleukin (AF-IL)-8 in PTD at <34 weeks significantly differed from those in delivery at </span><span style="font-family:Verdana;">≥34 weeks (p < 0.05, respectively). A multiple logistic regression analysis i</span><span style="font-family:Verdana;">dentified CM-IL-8 ≥ 803.5 ng/mL [21.3 (3.0 - 260), </span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.002] and cervical length ≤15 mm [17.1 (1.9 - 517), </span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.008] as independent risk factors for PTD at <34 weeks.</span><b><span style="font-family:Verdana;"> Conclusions:</span></b><span style="font-family:Verdana;"> Evaluation for cervical inflammation may be necessary for appropriate treatment strategies in asymptomatic pregnant women with a short cervix. Cervical inflammation warrants further study.</span></span></span></span>

关 键 词：Amniotic Fluid Cervical Mucus INTERLEUKIN-8 Preterm Delivery Sonographic Short Cervix 

分 类 号：O17[理学—数学]