Congenital Chylothorax Treated with Oral Sildenafil—Case Report from Nigeria and Review of Literature  

作　　者：Chinyere C. Uzodimma Saheed B. Sanni Deborah A. Madise-Wobo Charles C. Uzodimma Chinyere C. Uzodimma;Saheed B. Sanni;Deborah A. Madise-Wobo;Charles C. Uzodimma(X-Serve Children’s Hospital, Lagos, Nigeria;Federal Medical Centre, Abeokuta, Nigeria;Department of Paediatrics, University of Ottawa, Ottawa, Canada)

机构地区：[1]X-Serve Children’s Hospital, Lagos, Nigeria [2]Federal Medical Centre, Abeokuta, Nigeria [3]Department of Paediatrics, University of Ottawa, Ottawa, Canada

出　　处：《Open Journal of Pediatrics》2023年第2期189-195,共7页儿科学期刊（英文）

摘　　要：Congenital chylothorax, a condition in which chyle accumulates in the pleural cavity, is extremely rare. The reported incidence is 1 in 24,000 births. Medical treatment using octreotide as well as chemical and surgical pleurodesis has been reported, but also few reports on the successful use of Sildenafil exists. We herein report a case of congenital chylothorax referred to our Hospital at 7 days-old. Sildenafil was introduced on day 6 post intubation. Before the introduction of sildenafil, the peak total daily drainage was 106 ml/kg/day (340 mls/day), and after sildenafil was introduced, the total daily drainage dropped progressively to 10 ml/kg/day by day 11 post intubation. This case report highlights the successful use of oral Sildenafil for treatment of congenital chylothorax and also peculiarities of management related to a resource- constrained developing country setting in Africa.Congenital chylothorax, a condition in which chyle accumulates in the pleural cavity, is extremely rare. The reported incidence is 1 in 24,000 births. Medical treatment using octreotide as well as chemical and surgical pleurodesis has been reported, but also few reports on the successful use of Sildenafil exists. We herein report a case of congenital chylothorax referred to our Hospital at 7 days-old. Sildenafil was introduced on day 6 post intubation. Before the introduction of sildenafil, the peak total daily drainage was 106 ml/kg/day (340 mls/day), and after sildenafil was introduced, the total daily drainage dropped progressively to 10 ml/kg/day by day 11 post intubation. This case report highlights the successful use of oral Sildenafil for treatment of congenital chylothorax and also peculiarities of management related to a resource- constrained developing country setting in Africa.

关 键 词：CHYLOTHORAX CONGENITAL SILDENAFIL CHILDREN 

分 类 号：R56[医药卫生—呼吸系统]