Safety of Transcranial Direct Current Electrical Stimulation in Dermatomyositis: A Case Report  

作　　者：Rafael Giovani Missé Luiz Felipe Adsuara de Sousa Lucas de Macedo dos Santos Abrahão Fontes Baptista Clarice Tanaka Julia Maria D’Andréa Greve Samuel Katsuyuki Shinjo 

机构地区：[1]Division of Rheumatology,Faculdade de Medicina FMUSP,Universidade de Sao Paulo,Sao Paulo,SP,Brazil(BR) [2]Department of Physical Therapy,Speech Therapy and Occupational Therapy,Hospital das Clinicas HCFMUSP,Faculdade de Medicina,Universidade de Sao Paulo,Sao Paulo,SP,Brazil(BR) [3]Center for Mathematics,Computing and Cognition,Universidade Federal de ABC,SP,Brazil(BR) [4]Laboratory of Movement Studies,Institute of Orthopedics and Traumatology,Hospital das Clinicas HCFMUSP,Faculdade de Medicina,Universidade de Sao Paulo,Brazil(BR)

出　　处：《Open Journal of Rheumatology and Autoimmune Diseases》2020年第2期88-93,共6页风湿病与自身免疫疾病期刊（英文）

基　　金：Fundacao de Amparo a Pesquisa do Estado de Sao Paulo(FAPESP)#2019/12155-5 to RGM;Conselho Nacional de Desenvolvimento Cientifico e Tecnologico(CNPq)303379/2018-9 to SKS;Faculdade de Medicina da USP to SKS.

摘　　要：Transcranial direct current stimulation (tDCS) has emerged as a nonpharmacological tool in physical rehabilitation. There have currently no studies that evaluated the safety and efficacy of tDCS in patients with dermatomyositis. Case-report: Three adult women with dermatomyositis were allocated randomly to intervention (i-tDCS, one patient) or not (sham-tDCS, two patients) of three consecutive days of tDCS and evaluated in four periods: before-tDCS (PRE), 15 minutes after-tDCS (0th POST), 15 days after-tDCS (15th POST), and 30 days after-tDCS (30th POST). The tDCS was safe throughout the protocol, without disease relapsing or adverse effects related to tDCS. Furthermore, the tDCS increased the muscle torque and total work of dominant and non-dominant elbow flexors in the patient with i-tDCS, when compared to two patients with sham-tDCS. Conclusions: The tDCS was safe and appeared to influence long-term strength in the limb of the patient with stable dermatomyo-sitis.Transcranial direct current stimulation (tDCS) has emerged as a nonpharmacological tool in physical rehabilitation. There have currently no studies that evaluated the safety and efficacy of tDCS in patients with dermatomyositis. Case-report: Three adult women with dermatomyositis were allocated randomly to intervention (i-tDCS, one patient) or not (sham-tDCS, two patients) of three consecutive days of tDCS and evaluated in four periods: before-tDCS (PRE), 15 minutes after-tDCS (0th POST), 15 days after-tDCS (15th POST), and 30 days after-tDCS (30th POST). The tDCS was safe throughout the protocol, without disease relapsing or adverse effects related to tDCS. Furthermore, the tDCS increased the muscle torque and total work of dominant and non-dominant elbow flexors in the patient with i-tDCS, when compared to two patients with sham-tDCS. Conclusions: The tDCS was safe and appeared to influence long-term strength in the limb of the patient with stable dermatomyo-sitis.

关 键 词：DERMATOMYOSITIS NEUROMODULATION SAFETY Systemic Autoimmune Myopathies 

分 类 号：U28[交通运输工程—交通信息工程及控制]