Familial Forms of Spondyloarthritis Study of 100 Senegalese Multiplex Families  

作　　者：Adama Bah Chiekh Ahamadou Bamba Diaw Dieynaba Sala Tamara Kane Adama Doucouré Siddiki Charifah Ramadhane Bouchrane Harine Abdel Aziz Garba Aissatou N’diaye Mondukpe Joane Immanuelle Houansou Laurine Marlyse Adogle Yaye Aminata Gueye Moustapha Niasse Saidou Diallo Adama Bah;Chiekh Ahamadou Bamba Diaw;Dieynaba Sala Tamara Kane;Adama Doucouré;Siddiki Charifah;Ramadhane Bouchrane;Harine Abdel Aziz Garba;Aissatou N’diaye;Mondukpe Joane Immanuelle Houansou;Laurine Marlyse Adogle;Yaye Aminata Gueye;Moustapha Niasse;Saidou Diallo(Service de Rhumatologie, CHU Aristide Le Dantec, Dakar, Sngal;Service de Rhumatologie, Hpital National Ignace Deen Conakry, Conakry, Guine;Service de Mdecine Interne, Hpital Dalal Jamm de Dakar, Dakar, Sngal)

机构地区：[1]Service de Rhumatologie, CHU Aristide Le Dantec, Dakar, Sngal [2]Service de Rhumatologie, Hpital National Ignace Deen Conakry, Conakry, Guine [3]Service de Mdecine Interne, Hpital Dalal Jamm de Dakar, Dakar, Sngal

出　　处：《Open Journal of Rheumatology and Autoimmune Diseases》2024年第3期132-143,共12页风湿病与自身免疫疾病期刊（英文）

摘　　要：Introduction: Spondyloarthritis (SpA) comprises a group of chronic inflammatory rheumatic diseases characterized by predominant axial involvement. These include ankylosing spondylitis (AS), reactive arthritis (ReA), psoriatic arthritis (PsA), arthritis associated with inflammatory bowel diseases (IBD), SAPHO syndrome (Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis), juvenile spondyloarthritis (JSPA), and undifferentiated SpA. Their exact cause is unknown but is believed to stem from a combination of factors. The first familial forms were described by de Blécourt et al. in 1961. The objective was to evaluate the epidemiological, clinical, therapeutic and evolutionary aspects of familial forms of SpA and in particular, to prove the severity of the disease in family members compared to index cases in the rheumatology department of the Aristide Le Dantec University Hospital in Dakar. Methodology: This was a prospective, cross-sectional and descriptive study with an analytical aim on patients with the familial form of spondyloarthritis defined by the existence of at least one other family member with SpA outside the propositus, collected within the Aristide Le Dantec rheumatology department in Dakar over a period of 10 years between January 2012 and December 2021. There were two phases of study, the first of which consisted of collecting index cases with miserly SpA and the second of which consisted of family screening after consent. The data analysed were epidemiological, clinical, paraclinical, therapeutic and evolving. Results: Out of 100 families of 1905 members, 667 SpA patients included, i.e. a prevalence of 35%, including 225 (33.73%) men and 412 women (61.17%), i.e. a ratio of 1.8. The mean age at diagnosis among relatives was 26.3 years (range 13 and 80 years), 47.14 years among the propositus, in whom the mean age at onset was 36.26 years and that of relatives 49.9 years in the first degree, 15 years in the second degree and 1 year in the third degree. The time to diagnosis was 11.20 years in the fIntroduction: Spondyloarthritis (SpA) comprises a group of chronic inflammatory rheumatic diseases characterized by predominant axial involvement. These include ankylosing spondylitis (AS), reactive arthritis (ReA), psoriatic arthritis (PsA), arthritis associated with inflammatory bowel diseases (IBD), SAPHO syndrome (Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis), juvenile spondyloarthritis (JSPA), and undifferentiated SpA. Their exact cause is unknown but is believed to stem from a combination of factors. The first familial forms were described by de Blécourt et al. in 1961. The objective was to evaluate the epidemiological, clinical, therapeutic and evolutionary aspects of familial forms of SpA and in particular, to prove the severity of the disease in family members compared to index cases in the rheumatology department of the Aristide Le Dantec University Hospital in Dakar. Methodology: This was a prospective, cross-sectional and descriptive study with an analytical aim on patients with the familial form of spondyloarthritis defined by the existence of at least one other family member with SpA outside the propositus, collected within the Aristide Le Dantec rheumatology department in Dakar over a period of 10 years between January 2012 and December 2021. There were two phases of study, the first of which consisted of collecting index cases with miserly SpA and the second of which consisted of family screening after consent. The data analysed were epidemiological, clinical, paraclinical, therapeutic and evolving. Results: Out of 100 families of 1905 members, 667 SpA patients included, i.e. a prevalence of 35%, including 225 (33.73%) men and 412 women (61.17%), i.e. a ratio of 1.8. The mean age at diagnosis among relatives was 26.3 years (range 13 and 80 years), 47.14 years among the propositus, in whom the mean age at onset was 36.26 years and that of relatives 49.9 years in the first degree, 15 years in the second degree and 1 year in the third degree. The time to diagnosis was 11.20 years in the f

关 键 词：Familial Forms of Spondyloarthritis Propositus Senegal 

分 类 号：R59[医药卫生—内科学]