Preference in Dogs of Two Oral Endectoparasiticide Formulations: NexGard Spectra^®(Afoxolaner and Milbemycin Oxime) and Credelio^®Plus (Lotilaner and Milbemycin Oxime)  

作　　者：Nadège Perier Douglas S. Carithers William Russel Everett Phrutsamon Wongnak Karine Chalvet-Monfray Frederic Beugnet Nadège Perier;Douglas S. Carithers;William Russel Everett;Phrutsamon Wongnak;Karine Chalvet-Monfray;Frederic Beugnet(Boehringer Ingelheim Animal Health, Duluth, USA;BerTek, Inc., Greenbrier, USA;Université de Lyon, INRAE, VetAgro Sup, UMR EPIA, Marcy l’Etoile, France;Université Clermont Auvergne, INRAE, VetAgro Sup, UMR EPIA, Saint-Genès-Champanelle, France;Boehringer Ingelheim Animal Health, Lyon, France)

机构地区：[1]Boehringer Ingelheim Animal Health, Duluth, USA [2]BerTek, Inc., Greenbrier, USA [3]Université de Lyon, INRAE, VetAgro Sup, UMR EPIA, Marcy l’Etoile, France [4]Université Clermont Auvergne, INRAE, VetAgro Sup, UMR EPIA, Saint-Genès-Champanelle, France [5]Boehringer Ingelheim Animal Health, Lyon, France

出　　处：《Open Journal of Veterinary Medicine》2021年第8期289-298,共10页兽医学（英文）

摘　　要：Fleas and ticks are major ectoparasites of dogs globally. Their control is based on regular treatments with ectoparasiticides, which represent the most im<span>portant part of veterinary drugs </span><span style="font-family:;" "="">worth</span><span style="font-family:;" "=""> around 3 billion Euros per year. In </span><span style="font-family:;" "="">many <span>parts of the world, dogs are also at risk of infection by endoparasites like</span> <span>heartworm, eyeworm, and lungworm. In these areas, endectoparasiticide</span> formulations are used to prevent the risk of ecto- and endoparasite infections. <span>Since 2014, oral formulations of insecticidal-acaricidal drugs have been</span> launched, followed by endectoparasiticide formulation</span><span style="font-family:;" "="">s</span><span style="font-family:;" "="">. These oral formulations facilitate the treatment by the owners and are now </span><span style="font-family:;" "="">the </span><span style="font-family:;" "="">market leader</span><span style="font-family:;" "="">s</span><span style="font-family:;" "="">. Intense work has been done during their development to enhance their palatability through their consistence (hard to soft) and their flavors. Palatable oral formulations facilitate the dog-owner relationship and help ensur</span><span style="font-family:;" "="">ing</span><span style="font-family:;" "=""> compli<span>ance. The most </span><span>recent palatable formulations include isoxazoline as the ecto</span></span><span style="font-family:;" "="">-</span><span style="font-family:;" "="">parasiticide mole</span><span style="font-family:;" "="">cule. They also include anthelmintics (milbemycin oxime or moxidectin +</span><span style="font-family:;" "=""> pyrantel) to provide control of parasitic nematodes. Being very similar in term</span><span style="font-family:;" "="">s</span><span style="font-family:;" "=""> of spectrum of ac<span>tivity, any differences in palatability may be a key differentiating factor for the</span> owners. The presentFleas and ticks are major ectoparasites of dogs globally. Their control is based on regular treatments with ectoparasiticides, which represent the most im<span>portant part of veterinary drugs </span><span style="font-family:;" "="">worth</span><span style="font-family:;" "=""> around 3 billion Euros per year. In </span><span style="font-family:;" "="">many <span>parts of the world, dogs are also at risk of infection by endoparasites like</span> <span>heartworm, eyeworm, and lungworm. In these areas, endectoparasiticide</span> formulations are used to prevent the risk of ecto- and endoparasite infections. <span>Since 2014, oral formulations of insecticidal-acaricidal drugs have been</span> launched, followed by endectoparasiticide formulation</span><span style="font-family:;" "="">s</span><span style="font-family:;" "="">. These oral formulations facilitate the treatment by the owners and are now </span><span style="font-family:;" "="">the </span><span style="font-family:;" "="">market leader</span><span style="font-family:;" "="">s</span><span style="font-family:;" "="">. Intense work has been done during their development to enhance their palatability through their consistence (hard to soft) and their flavors. Palatable oral formulations facilitate the dog-owner relationship and help ensur</span><span style="font-family:;" "="">ing</span><span style="font-family:;" "=""> compli<span>ance. The most </span><span>recent palatable formulations include isoxazoline as the ecto</span></span><span style="font-family:;" "="">-</span><span style="font-family:;" "="">parasiticide mole</span><span style="font-family:;" "="">cule. They also include anthelmintics (milbemycin oxime or moxidectin +</span><span style="font-family:;" "=""> pyrantel) to provide control of parasitic nematodes. Being very similar in term</span><span style="font-family:;" "="">s</span><span style="font-family:;" "=""> of spectrum of ac<span>tivity, any differences in palatability may be a key differentiating factor for the</span> owners. The present

关 键 词：PREFERENCE Chewable Tablet NexGard Spectra^® Credelio^® Plus PALATABILITY 

分 类 号：O17[理学—数学]