Persistence of Healthcare-Associated (Nosocomial) Infections Due to Inadequate Hand Hygiene: Part 1—Biological and Treatment Factors  

作　　者：Robert B. Raffa Joseph V. Pergolizzi Robert Taylor Sanjib Choudhuri Robert Rodenbeck 

机构地区：[1]University of Arizona College of Pharmacy, Tucson, AZ, USA [2]Professor Emeritus, Temple University School of Pharmacy, Philadelphia, PA, USA [3]Neumentum, Inc., Palo Alto, CA, USA [4]NEMA Research, Inc., Naples, FL, USA [5]Delta Faucet Co., Indianapolis, IN, USA

出　　处：《Pharmacology & Pharmacy》2018年第8期293-309,共17页药理与制药（英文）

摘　　要：The most frequent adverse event in the healthcare delivery system is acquisition of an infection within a healthcare facility. Since infection control measures are known, simple, and low-cost, we examine why the problem of healthcare-associated infections persists. Hundreds of millions of patients each year are affected by a healthcare-associated infection, with negative medical outcome and financial cost. It is a major public health problem even in countries with advanced healthcare systems. This is a bit perplexing, given that hygienic practices have been known and actively promoted. The objective is to address the question: doesn’t the use of disinfection, sterilization, handwashing, and alcohol rubs prevent the spread of pathogenic organisms? We conclude that the persistent high prevalence of nosocomial infections despite known hygienic practices is attributable to two categories of factors: biological and inherent shortcomings of some practices (considered in Part 1), and human factors (considered in Part 2). A new approach is presented in Part 3.The most frequent adverse event in the healthcare delivery system is acquisition of an infection within a healthcare facility. Since infection control measures are known, simple, and low-cost, we examine why the problem of healthcare-associated infections persists. Hundreds of millions of patients each year are affected by a healthcare-associated infection, with negative medical outcome and financial cost. It is a major public health problem even in countries with advanced healthcare systems. This is a bit perplexing, given that hygienic practices have been known and actively promoted. The objective is to address the question: doesn’t the use of disinfection, sterilization, handwashing, and alcohol rubs prevent the spread of pathogenic organisms? We conclude that the persistent high prevalence of nosocomial infections despite known hygienic practices is attributable to two categories of factors: biological and inherent shortcomings of some practices (considered in Part 1), and human factors (considered in Part 2). A new approach is presented in Part 3.

关 键 词：Infection NOSOCOMIAL Hospital HEALTHCARE-ASSOCIATED Hygiene HANDWASHING 

分 类 号：R5[医药卫生—内科学]