Additive Efficiency of Fipronil + Methoprene Compared to Fipronil Alone against <i>Rhipicephalus sanguineus</i>Ticks in Naturally Infested Dogs  

作　　者：Froylán Ibarra-Velarde Yolanda Vera-Montenegro Yazmín Acala-Canto Irene Cruz-Mendoza Froylán Ibarra-Velarde;Yolanda Vera-Montenegro;Yazmín Acala-Canto;Irene Cruz-Mendoza(Departamento de Parasitología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Ciudad de México, México)

机构地区：[1]Departamento de Parasitología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Ciudad de México, México

出　　处：《Pharmacology & Pharmacy》2020年第8期174-187,共14页药理与制药（英文）

摘　　要：The acaricidal efficiency of fipronil alone and fipronil + methoprene compared to commercial fipronil and commercial fipronil + methoprene, applied by the epicutaneous route (spot-on) in dogs naturally infested with ticks, was assessed. Thirty dogs infested with high loads of ticks were used. On day 0, the dogs were divided into 5 groups of 6 animals each. Each animal was duly identified for individual and group monitoring. Treatments were made based on body weight according to manufacturer’s instructions. Group 1<span style="font-family:;" "=""> </span><span style="font-family:Verdana;">(G1) received 10.0% fipronil at a single dose of a pipette applied by epicutaneous</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">route in the base of the neck. G2 received 10% fipronil + 10% methoprene in single application similarly to G1. G3 was treated with 9.8% commercial fipronil as before mentioned. G4 received commercial 9.8% fipronil + 9.8% methoprene applied as in previous groups. G5 served as an infected untreated control. Animals were examined</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">by</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">thumb tick counts on days 0 (Treatment day), 3, 7, 14, 21 and 28. Efficacy was measured as a percentage of tick reduction in the treated groups relative to the untreated control. Results indicated an overall efficacy of 88.2%, 93%, 90.4% and 99.3%, respectively. There was no significant statistical difference between the treated groups (P < 0.05), neither in sex nor in weight. Engorged ticks were the most frequent, followed by the nymph group. However, by the end of the study these data were reversed due to the fact that only small larvae were found, which we interpreted came from engorged ticks that released their progeny before dying and a month later their offspring began to be observed present</span><span style="font-family:Verdana;">ly</span><span style="font-family:VerdanaThe acaricidal efficiency of fipronil alone and fipronil + methoprene compared to commercial fipronil and commercial fipronil + methoprene, applied by the epicutaneous route (spot-on) in dogs naturally infested with ticks, was assessed. Thirty dogs infested with high loads of ticks were used. On day 0, the dogs were divided into 5 groups of 6 animals each. Each animal was duly identified for individual and group monitoring. Treatments were made based on body weight according to manufacturer’s instructions. Group 1<span style="font-family:;" "=""> </span><span style="font-family:Verdana;">(G1) received 10.0% fipronil at a single dose of a pipette applied by epicutaneous</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">route in the base of the neck. G2 received 10% fipronil + 10% methoprene in single application similarly to G1. G3 was treated with 9.8% commercial fipronil as before mentioned. G4 received commercial 9.8% fipronil + 9.8% methoprene applied as in previous groups. G5 served as an infected untreated control. Animals were examined</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">by</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">thumb tick counts on days 0 (Treatment day), 3, 7, 14, 21 and 28. Efficacy was measured as a percentage of tick reduction in the treated groups relative to the untreated control. Results indicated an overall efficacy of 88.2%, 93%, 90.4% and 99.3%, respectively. There was no significant statistical difference between the treated groups (P < 0.05), neither in sex nor in weight. Engorged ticks were the most frequent, followed by the nymph group. However, by the end of the study these data were reversed due to the fact that only small larvae were found, which we interpreted came from engorged ticks that released their progeny before dying and a month later their offspring began to be observed present</span><span style="font-family:Verdana;">ly</span><span style="font-family:Verdana

关 键 词：TICKS DOGS Efficacy FIPRONIL Fipronil + Methoprene 

分 类 号：S43[农业科学—农业昆虫与害虫防治]