Exercise Blood Pressure Response and Cardiometabolic Risk Factors in Middle Aged Women: A MONET Group Study  

作　　者：Joseph Abdulnour Marie-Noëlle Lacroix Pierre Boulay Éric Doucet Martin Brochu Rémi Rabasa-Lhoret Jean-Marc Lavoie Denis Prud’homme Joseph Abdulnour;Marie-Noëlle Lacroix;Pierre Boulay;Éric Doucet;Martin Brochu;Rémi Rabasa-Lhoret;Jean-Marc Lavoie;Denis Prud’homme(School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada;Institut de recherche de l’H?pital Montfort, Ottawa, ON, Canada;Faculté des sciences de l’activité physique, Université de Sherbrooke, Sherbrooke, QC, Canada;Research Centre on Aging, Social Services and Health Centre—University Institute of Geriatrics of Sherbrooke, Sherbrooke, QC, Canada;Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC, Canada;Department of Kinesiology, Université de Montréal, Montréal, QC, Canada)

机构地区：[1]School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada [2]Institut de recherche de l’H?pital Montfort, Ottawa, ON, Canada [3]Faculté des sciences de l’activité physique, Université de Sherbrooke, Sherbrooke, QC, Canada [4]Research Centre on Aging, Social Services and Health Centre—University Institute of Geriatrics of Sherbrooke, Sherbrooke, QC, Canada [5]Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC, Canada [6]Department of Kinesiology, Université de Montréal, Montréal, QC, Canada

出　　处：《World Journal of Cardiovascular Diseases》2016年第6期157-165,共9页心血管病（英文）

摘　　要：Objective: To investigate if an exaggerated peak exercise systolic blood pressure (peak ESBP) is associated with alteration of cardiometabolic risk factors and predict future resting hypertension in middle aged women. Methods: Data analysis was performed in 95 healthy normotensive premeno-pausal women at baseline and 84 after 5-year follow-up (age, 49.9 ± 1.9 years;BMI, 23.3 ± 2.2 kg/m2;resting BP, 117/73 ± 11.8/7.6 mmHg). Blood pressure was measured at rest and during a progressive exercise test on treadmill. Women were divided into two groups according to their peak ESBP <190 mmHg vs. ≥190 mmHg. Other outcome measures were: cardiorespiratory fitness (VO2 peak), body composition, body fat distribution and fasting plasma lipids, glucose and insulin levels. Results: 15% and 27% of women presented an exaggerated peak ESBP response (≥190 mmHg) at baseline and year 5 respectively. Linear mixed model repeated measures analysis revealed higher values of fasting glucose, resting systolic and diastolic BP in women with an exaggerated peak ESBP (≥190 mmHg) compared to women with a peak ESBP (<190 mmHg). No significant difference was observed between the two groups for VO2 peak, body composition and body fat distribution indices and other cardiometabolic risk factors. Finally, baseline peak ESBP was not a significant risk factor for future resting hypertension (OR: 2.96, 95%CI [0.48 - 18.12];P = 0.24). Conclusion: Our results, despite being non significant, are of great interest because in healthy and active premenopausal women, exaggerated peak ESBP is not predictive of future hypertension after 5-year follow-up throughout menopause transition.Objective: To investigate if an exaggerated peak exercise systolic blood pressure (peak ESBP) is associated with alteration of cardiometabolic risk factors and predict future resting hypertension in middle aged women. Methods: Data analysis was performed in 95 healthy normotensive premeno-pausal women at baseline and 84 after 5-year follow-up (age, 49.9 ± 1.9 years;BMI, 23.3 ± 2.2 kg/m2;resting BP, 117/73 ± 11.8/7.6 mmHg). Blood pressure was measured at rest and during a progressive exercise test on treadmill. Women were divided into two groups according to their peak ESBP <190 mmHg vs. ≥190 mmHg. Other outcome measures were: cardiorespiratory fitness (VO2 peak), body composition, body fat distribution and fasting plasma lipids, glucose and insulin levels. Results: 15% and 27% of women presented an exaggerated peak ESBP response (≥190 mmHg) at baseline and year 5 respectively. Linear mixed model repeated measures analysis revealed higher values of fasting glucose, resting systolic and diastolic BP in women with an exaggerated peak ESBP (≥190 mmHg) compared to women with a peak ESBP (<190 mmHg). No significant difference was observed between the two groups for VO2 peak, body composition and body fat distribution indices and other cardiometabolic risk factors. Finally, baseline peak ESBP was not a significant risk factor for future resting hypertension (OR: 2.96, 95%CI [0.48 - 18.12];P = 0.24). Conclusion: Our results, despite being non significant, are of great interest because in healthy and active premenopausal women, exaggerated peak ESBP is not predictive of future hypertension after 5-year follow-up throughout menopause transition.

关 键 词：Blood pressure Exercise Blood Pressure Exaggerated Peak Exercise Systolic Blood Pressure Hy-pertension Cardiometabolic Risk Factors 

分 类 号：R54[医药卫生—心血管疾病]