Protocol of Investigation on Sudden Death at Autopsy, Including Molecular, Genetic and Toxicology Testing  

作　　者：Gaetano Thiene Donata Favretto Gaetano Thiene;Donata Favretto(Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padova, Italy)

机构地区：[1]Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padova, Italy

出　　处：《World Journal of Cardiovascular Surgery》2024年第6期78-86,共9页心血管外科国际期刊（英文）

摘　　要：The role of the autopsy: 1) Whether the death is ascribable to a natural or unnatural cause and when natural, if cardiac or extra-cardiac;2) The nosology of the cardiac diseases and the mechanism of cardiac death, whether arrhythmic or mechanical;3) If the cardiac disease is inherited, screening and counselling of the next of kin is required. About 30% of sudden deaths is ascribable to genetically determined morbid entities, mostly transmissible with the autosomal dominant pattern of inheritance, so that 50% of the first degree relatives are genetically affected (“carriers”) and exposed at risk;4) If toxic or illicit drug abuse was involved.The role of the autopsy: 1) Whether the death is ascribable to a natural or unnatural cause and when natural, if cardiac or extra-cardiac;2) The nosology of the cardiac diseases and the mechanism of cardiac death, whether arrhythmic or mechanical;3) If the cardiac disease is inherited, screening and counselling of the next of kin is required. About 30% of sudden deaths is ascribable to genetically determined morbid entities, mostly transmissible with the autosomal dominant pattern of inheritance, so that 50% of the first degree relatives are genetically affected (“carriers”) and exposed at risk;4) If toxic or illicit drug abuse was involved.

关 键 词：Family Screening GENETICS INHERITANCE Molecular Autopsy Sudden Death TOXICOLOGY 

分 类 号：R54[医药卫生—心血管疾病]